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How to get fromSantiago to Medellínby bus, plane, or ferry

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There are 5 ways to get from Santiago to Medellín by bus, plane, or ferry

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus to Panama Pacific International Airport, fly to Medellin Jose Marie Cordova

    best
    1. Take the bus from Santiago to Albrookbus bus
    2. Fly from Panama Pacific International Airport (BLB) to Medellin Jose Marie Cordova (MDE)plane plane BLB - MDE
    8h 17m
    $159–252

  2. Bus, Tour, ferry

    1. Take the bus from Santiago to Gran Terminal Nacional de Transportebus bus
    2. Take the bus from Panama City to Cartíbus bus
    3. Take the ferry from Cartí to Sapzurroferry ferry
    4. Take the ferry from Sapzurro to Necocliferry ferry
    5. Take the bus from Necoclí to Terminal del Nortebus bus
    5d 21h

  3. Bus to Tocumen International Airport, fly to Medellin Jose Marie Cordova

    1. Take the bus from Santiago to Paraíso, Panamá Provincebus bus
    2. Fly from Tocumen International Airport (PTY) to Medellin Jose Marie Cordova (MDE)plane plane PTY - MDE
    9h 7m
    $275–490

  4. Bus to David, fly to Medellin Jose Marie Cordova

    1. Take the bus from Santiago to Davidbus bus
    2. Fly from David (DAV) to Medellin Jose Marie Cordova (MDE)plane plane DAV - MDE
    10h 13m

  5. Bus to Tocumen International Airport, fly to Enrique Olaya Herrera Airport

    1. Take the bus from Santiago to Paraíso, Panamá Provincebus bus
    2. Fly from Tocumen International Airport (PTY) to Enrique Olaya Herrera Airport (EOH)plane plane PTY - EOH
    10h 9m
    $170–760

Panama Pacific International Airport (BLB) to Medellin Jose Marie Cordova (MDE) flights

Calendar11Weekly Planes
Duration1h 17mAverage Duration
Ticket$97Cheapest Price
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Questions & Answers

Map of how to get from Santiago to Medellín.ExpandLaunch map view
  • Distance: 845.4 km
  • Duration: 8h 17m

What companies run services between Santiago, Panama and Medellín, Colombia?

There is no direct connection from Santiago to Medellín. However, you can take the bus to Albrook, take the taxi to Panama Pacific International Airport (BLB) airport, fly to Medellin Jose Marie Cordova (MDE), walk to Medellin Jose Marie Cordova Airport, then take the taxi to Medellín. Alternatively, you can take a bus from Santiago to Terminal del Norte via Gran Terminal Nacional de Transporte, Albrook, Iglesia del Carmen, Panama City, Cartí, Cartí, Sapzurro, Sapzurro, Necocli, and Necoclí in around 5d 21h.

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