Rome2Rio

How to get fromSantiago de Cuba to Cayo Santa Maríaby bus, train, car, or plane

Find Transport to Cayo Santa María

See all options

There are 6 ways to get from Santiago de Cuba to Cayo Santa María by bus, train, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus via Santa Clara

    best
    1. Take the bus from Santiago de Cuba to Santa Clarabus bus Santa Clara
    2. Take the bus from Santa Clara to Cayo Santa Maríabus bus Santa Clara
    12h 30m
    $12–25

  2. Train, bus

    1. Take the train from Santiago de Cuba to Santa Claratrain train 12 / ...
    2. Take the bus from Santa Clara to Cayo Santa Maríabus bus Santa Clara
    16h 14m
    $12–27

  3. Drive 618.3 km

    1. Drive from Santiago de Cuba to Cayo Santa Maríacar car 618.3 km
    9h 9m
    $71–102

  4. Fly from Antonio Maceo International Airport, bus

    1. Fly from Antonio Maceo International Airport (SCU) to Abel Santamaría Airport (SNU)plane plane SCU - SNU
    2. Take the bus from Santa Clara to Cayo Santa Maríabus bus
    19h 43m
    $105–477

  5. Bus

    1. Take the bus from Terminal de Ómnibus Nacionales Santiago de Cuba to Santa Clarabus bus La Habana Vía Holguín / ...
    2. Take the bus from Santa Clara to Cayo Santa Maríabus bus Santa Clara
    15h 5m
    $54–81

  6. Bus to Frank País International Airport, fly, bus

    1. Take the bus from Terminal de Ómnibus Nacionales Santiago de Cuba to Holguin Airportbus bus
    2. Fly from Frank País International Airport (HOG) to Abel Santamaría Airport (SNU)plane plane HOG - SNU
    3. Take the bus from Santa Clara to Cayo Santa Maríabus bus
    30h 31m
    $107–436

Antonio Maceo International Airport (SCU) to Abel Santamaría Airport (SNU) flights

Calendar9Weekly Planes
Duration20h 53mAverage Duration
Ticket$84Cheapest Price
See schedules

Questions & Answers

Map of how to get from Santiago de Cuba to Cayo Santa María.ExpandLaunch map view
  • Distance: 713.6 km
  • Duration: 12h 30m

What companies run services between Santiago de Cuba and Cayo Santa María, Villa Clara, Cuba?

You can take a bus from Santiago de Cuba to Cayo Santa María via Parque, Vc, and Santa Clara in around 12h 30m.

Airlines
Train operators
Bus operators

Want to know more about travelling around the world?

Rome2Rio's Travel Guide series provide vital information for the global traveller. Read our range of informative guides on popular transport routes and companies - including How to travel India's Golden Triangle, Getting to Rome from the airport, and Which London airport should I choose? - to help you get the most out of your next trip.