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How to get fromSantiago de Cuba to Panama City Beachby plane, car, or bus

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There are 6 ways to get from Santiago de Cuba to Panama City Beach by plane, car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Antonio Maceo International Airport to Destin–Fort Walton Beach Airport, drive

    best
    1. Fly from Antonio Maceo International Airport (SCU) to Destin–Fort Walton Beach Airport (VPS)plane plane SCU - VPS
    2. Drive from Destin–Fort Walton Beach Airport (VPS) to Panama City Beachcar car
    14h 42m
    $114–520

  2. Bus to Frank País International Airport, fly to Destin–Fort Walton Beach Airport, drive

    cheapest
    1. Take the bus from Terminal de Ómnibus Nacionales Santiago de Cuba to Holguin Airportbus bus
    2. Fly from Frank País International Airport (HOG) to Destin–Fort Walton Beach Airport (VPS)plane plane HOG - VPS
    3. Drive from Destin–Fort Walton Beach Airport (VPS) to Panama City Beachcar car
    15h 39m
    $111–479

  3. Fly Antonio Maceo International Airport to Tallahassee, bus

    1. Fly from Antonio Maceo International Airport (SCU) to Tallahassee (TLH)plane plane SCU - TLH
    2. Take the bus from Tallahassee to Panama City Beach Bus Stationbus bus
    11h 31m
    $171–723

  4. Fly Antonio Maceo International Airport to Pensacola International Airport, bus

    1. Fly from Antonio Maceo International Airport (SCU) to Pensacola International Airport (PNS)plane plane SCU - PNS
    2. Take the bus from Pensacola Airport to Panama City Beach Bus Stationbus bus
    10h 56m
    $117–484

  5. Bus to Frank País International Airport, fly to Pensacola International Airport, bus

    1. Take the bus from Terminal de Ómnibus Nacionales Santiago de Cuba to Holguin Airportbus bus
    2. Fly from Frank País International Airport (HOG) to Pensacola International Airport (PNS)plane plane HOG - PNS
    3. Take the bus from Pensacola Airport to Panama City Beach Bus Stationbus bus
    13h 31m
    $114–443

  6. Bus to Frank País International Airport, fly to Tallahassee, bus

    1. Take the bus from Terminal de Ómnibus Nacionales Santiago de Cuba to Holguin Airportbus bus
    2. Fly from Frank País International Airport (HOG) to Tallahassee (TLH)plane plane HOG - TLH
    3. Take the bus from Tallahassee to Panama City Beach Bus Stationbus bus
    17h 20m
    $163–642

Antonio Maceo International Airport (SCU) to Destin–Fort Walton Beach Airport (VPS) flights

Calendar9Weekly Planes
Duration12h 10mAverage Duration
Ticket$104Cheapest Price
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Questions & Answers

Map of how to get from Santiago de Cuba to Panama City Beach.ExpandLaunch map view
  • Distance: 1,051.3 mi
  • Duration: 14h 42m

What companies run services between Santiago de Cuba and Panama City Beach, FL, USA?

There is no direct connection from Santiago de Cuba to Panama City Beach. However, you can take the bus to Santiago Airport, walk to Antonio Maceo International Airport (SCU) airport, fly to Destin–Fort Walton Beach Airport (VPS), then drive to Panama City Beach. Alternatively, you can take the bus to Santiago Airport, walk to Antonio Maceo International Airport (SCU) airport, fly to Tallahassee (TLH), take the taxi to Tallahassee, take the bus to Panama City Beach Bus Station, then take the taxi to Panama City Beach.

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