How to get fromSantiago de Cuba to Santiagoby plane or bus

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There are 3 ways to get from Santiago de Cuba to Santiago by plane or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

Fly from Antonio Maceo International Airport
best
1. Fly from Antonio Maceo International Airport (SCU) to Comodoro Arturo Merino Benítez International Airport (SCL)plane SCU - SCL
20h 34m
$295–1,107
Bus to Ignacio Agramonte International Airport, fly
cheapest
1. Take the bus from Santiago de Cuba to Camagüeybus
2. Fly from Ignacio Agramonte International Airport (CMW) to Comodoro Arturo Merino Benítez International Airport (SCL)plane CMW - SCL
20h 27m
$255–959
Bus to Frank País International Airport, fly
1. Take the bus from Terminal de Ómnibus Nacionales Santiago de Cuba to Holguin Airportbus
2. Fly from Frank País International Airport (HOG) to Comodoro Arturo Merino Benítez International Airport (SCL)plane HOG - SCL
18h 38m
$277–976

Antonio Maceo International Airport (SCU) to Comodoro Arturo Merino Benítez International Airport (SCL) flights

12Weekly Planes

18h 46mAverage Duration

$293Cheapest Price

Questions & Answers

Map of how to get from Santiago de Cuba to Santiago.

Launch map view

Distance: 5,979 km
Duration: 20h 34m

What companies run services between Santiago de Cuba and Santiago, Chile?

American Airlines, LATAM Chile, and two other airlines fly from Antonio Maceo International Airport (SCU) to Comodoro Arturo Merino Benítez International Airport (SCL) twice daily.

Airlines

Bus operators

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Santiago(opens in a new window), Chile(opens in a new window)

Santiago, also known as Santiago de Chile, is the capital and largest city of Chile and one of the largest cities in the Americas. It is located in the country's central valley and is the center of the Santiago Metropolitan Region, which has a population of 7 million, representing 40% of Chile's total population. Most of the city is situated between above sea level.

Things to do in Santiago

Fantasilandia(Opens in a new window)

Fantasilandia is a Chilean amusement park. The park opened in 1978 and is located in a corner of O'Higgins Park in Santiago, Chile.

Places to stay in Santiago

Hotel Plaza San Francisco(Opens in a new window)

8.9Fabulous

Hotel Cumbres Lastarria(Opens in a new window)

9.0Fabulous

Hotel Luciano K(Opens in a new window)

8.6Fabulous

Plaza Huelen(Opens in a new window)

9.3Superb

Rome2Rio makes travelling from Santiago de Cuba to Santiago easy.

Rome2Rio is a door-to-door travel information and booking engine, helping you get to and from any location in the world. Find all the transport options for your trip from Santiago de Cuba to Santiago right here. Rome2Rio displays up to date schedules, route maps, journey times and estimated fares from relevant transport operators, ensuring you can make an informed decision about which option will suit you best. Rome2Rio also offers online bookings for selected operators, making reservations easy and straightforward.