There are 4 ways to get from Santiago to Cusco by plane, bus, or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly
best- Fly from Comodoro Arturo Merino Benítez International Airport (SCL) to Alejandro Velasco Astete International Airport (CUZ)plane SCL - CUZ
5h 55m$132–312Bus
cheapest- Take the bus from Terminal San Borja to Terminal Rodoviario de Aricabus
- Take the bus from Terminal Internacional to Tacnabus
- Take the bus from Tacna Bus Station to Cusco Bus Stationbus
47h 1m$89–170Drive 2,876.3 km
- Drive from Santiago to Cuscocar 2,876.3 km
38h 49m$433–625Bus via Oruro Airport (ORU)
- Take the bus from Terminal Alameda - Turbus to Orurobus
- Take the bus from Oruro to La Pazbus
- Take the bus from La Paz to Cuscobus
2d 6h$102–112
Comodoro Arturo Merino Benítez International Airport (SCL) to Alejandro Velasco Astete International Airport (CUZ) flights
Comparing Your Travel Options
The cheapest way to get from Santiago to Cusco is to bus which costs $85 - $170 and takes 47h 1m.
The fastest way to get from Santiago to Cusco is to fly which takes 5h 55m and costs $130 - $320.
No, there is no direct bus from Santiago to Cusco station. However, there are services departing from Terminal San Borja and arriving at Cusco Bus Station via Terminal Internacional and Tacna Bus Station. The journey, including transfers, takes approximately 47h 1m.
The distance between Santiago and Cusco is 2225 km. The road distance is 2876.3 km.
The best way to get from Santiago to Cusco without a car is to bus which takes 47h 1m and costs $85 - $170.
It takes approximately 5h 55m to get from Santiago to Cusco, including transfers.
Santiago to Cusco bus services, operated by Pullman Bus, depart from Terminal San Borja station.
The best way to get from Santiago to Cusco is to fly which takes 5h 55m and costs $130 - $320. Alternatively, you can bus, which costs $85 - $170 and takes 47h 1m.
Santiago to Cusco bus services, operated by Pullman Bus, arrive at Terminal Rodoviario de Arica station.
Cusco is 2h behind Santiago. It is currently 8:52 PM in Santiago and 6:52 PM in Cusco.
What companies run services between Santiago, Chile and Cusco, Peru?
Sky Airline, LATAM Chile, and JetSMART fly from Comodoro Arturo Merino Benítez International Airport (SCL) to Alejandro Velasco Astete International Airport (CUZ) every 3 hours. Alternatively, you can take a bus from Terminal San Borja to Cusco Bus Station via Terminal Rodoviario de Arica, Terminal Internacional, and Tacna Bus Station in around 47h 1m.
- Website
- latam.com
Flights from Comodoro Arturo Merino Benítez International Airport to Alejandro Velasco Astete International Airport
- Ave. Duration
- 3h 30m
- When
- Every day
- Estimated price
- $150–290
Flights from Comodoro Arturo Merino Benítez International Airport to Alejandro Velasco Astete International Airport via Lima
- Ave. Duration
- 6h 14m
- When
- Every day
- Estimated price
- $150–290
- Website
- skyairline.com
Flights from Comodoro Arturo Merino Benítez International Airport to Alejandro Velasco Astete International Airport
- Ave. Duration
- 3h 30m
- When
- Monday, Wednesday, Friday, and Sunday
- Estimated price
- $120–310
Flights from Comodoro Arturo Merino Benítez International Airport to Alejandro Velasco Astete International Airport via Lima
- Ave. Duration
- 6h 29m
- When
- Every day
- Estimated price
- $120–310
- Website
- jetsmart.com
Flights from Comodoro Arturo Merino Benítez International Airport to Alejandro Velasco Astete International Airport via Lima
- Ave. Duration
- 6h 18m
- When
- Saturday and Sunday
- Estimated price
- $110–340
- Phone
- +56 600 600 0018
- [email protected]
- Website
- pullmanbus.cl
Bus from Terminal San Borja to Terminal Rodoviario de Arica
- Ave. Duration
- 29h 5m
- Frequency
- 5 times a day
- Estimated price
- $60–80
- Schedules at
- pullmanbus.cl
- Book at
- pullmanbus.cl
- Salón Cama
- $60–80
- [email protected]
- Website
- Pullman San Andres
Bus from Terminal San Borja to Terminal Rodoviario de Arica
- Ave. Duration
- 29h 55m
- Frequency
- Every 4 hours
- Estimated price
- $60–130
- Schedules at
- Pullman San Andres
- Semi Cama
- $85–120
- Cama
- $95–130
- Phone
- +56 58 222 8603
- [email protected]
- Website
- Recorrido Norte Grande
Bus from Terminal Internacional to Tacna
- Ave. Duration
- 1h
- Frequency
- Hourly
- Estimated price
- $5
- Website
- Recorrido Norte Grande
Bus from Tacna Bus Station to Cusco Bus Station
- Ave. Duration
- 15h 30m
- Frequency
- Twice daily
- Estimated price
- $24–35
- Schedules at
- Expreso Turismo San Martin Nobleza
- Phone
- +591 2527 7355
- [email protected]
- Website
- Jet Nort Super Class
Bus from Terminal Alameda - Turbus to Oruro
- Ave. Duration
- 33h 2m
- Frequency
- 4 times a week
- Estimated price
- $43
- Schedules at
- Jet Nort Super Class
- Phone
- +59 128 1779
- [email protected]
- Website
- Predilecto Tours
Bus from Oruro to La Paz
- Ave. Duration
- 4h 30m
- Frequency
- Once daily
- Website
- Predilecto Tours
- Phone
- +591 466-60443
- [email protected]
- Website
- Autotransportes SAMA
Bus from Oruro to La Paz
- Ave. Duration
- 5h 6m
- Frequency
- Once daily
- Estimated price
- $13–23
- Schedules at
- Autotransportes SAMA
- Phone
- +591 2228 3843
- [email protected]
- Website
- facebook.com
Bus from La Paz to Cusco
- Ave. Duration
- 14h
- Frequency
- Twice daily
- Estimated price
- $40–340
- Book at
- Tickets Bolivia
- Phone
- +591 2 228 1920
- [email protected]
- Website
- facebook.com
Bus from La Paz to Cusco
- Ave. Duration
- 15h
- Frequency
- Once daily
- Estimated price
- $44
- Schedules at
- redbus.pe
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Rome2Rio's Travel Guide series provide vital information for the global traveller. Read our range of informative guides on popular transport routes and companies - including What documents do I need to cross Niagara Falls?, Travelling to and around Russia for the 2018 FIFA World Cup, and Travel Insider: Top Japan travel tips by Beatrix Holland - to help you get the most out of your next trip.
Booking & Getting There
Yes, the driving distance between Santiago to Cusco is 2876 km. It takes approximately 38h 49m to drive from Santiago to Cusco.
There are 1449+ hotels available in Cusco.
























