Rome2Rio

How to get fromSantiago to Guayaquilby plane, bus, or car

Find Transport to Guayaquil

See all options

There are 6 ways to get from Santiago to Guayaquil by plane, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Comodoro Arturo Merino Benítez International Airport (SCL) to José Joaquín De Olmedo International Airport (GYE)plane plane SCL - GYE
    7h 43m
    $242–552

  2. Bus #2

    cheapest
    1. Take the bus from Terminal Sur de Santiago to Gran Terminal Terrestre Plaza Nortebus bus
    2. Take the bus from Gran Terminal Terrestre Plaza Norte to Tumbesbus bus
    3. Take the bus from Tumbes to Terminal Terrestre de Guayaquilbus bus
    3d 10h
    $142–223

  3. Bus via Tumbes

    1. Take the bus from Terminal San Borja to Gran Terminal Terrestre Plaza Nortebus bus
    2. Take the bus from Gran Terminal Terrestre Plaza Norte to Tumbesbus bus
    3. Take the bus from Tumbes to Terminal Terrestre de Guayaquilbus bus
    2d 19h
    $259–329

  4. Drive 4,694.9 km

    1. Drive from Santiago to Guayaquilcar car 4,694.9 km
    2d 12h
    $579–837

  5. Bus

    1. Take the bus from Terminal San Borja to Gran Terminal Terrestre Plaza Nortebus bus Cúcuta
    2. Take the bus from Gran Terminal Terrestre Plaza Norte to Terminal Terrestre de Guayaquilbus bus Lima-Cucuta / ...
    3d 1h
    $316–384

  6. Bus #3

    1. Take the bus from Terminal Sur de Santiago to Gran Terminal Terrestre Plaza Nortebus bus Lima
    2. Take the bus from Gran Terminal Terrestre Plaza Norte to Terminal Terrestre de Guayaquilbus bus Lima-Cucuta / ...
    3d 11h
    $200–298

Comodoro Arturo Merino Benítez International Airport (SCL) to José Joaquín De Olmedo International Airport (GYE) flights

Calendar49Weekly Planes
Duration8h 23mAverage Duration
Ticket$181Cheapest Price
See schedules

Questions & Answers

Map of how to get from Santiago to Guayaquil.ExpandLaunch map view
  • Distance: 3,615.2 km
  • Duration: 7h 43m

What companies run services between Santiago, Chile and Guayaquil, Ecuador?

LATAM Chile, Avianca - Aerovías del Continente Americano S.A., and Copa Airlines fly from Comodoro Arturo Merino Benítez International Airport (SCL) to José Joaquín De Olmedo International Airport (GYE) every 4 hours. Alternatively, you can take a bus from Terminal San Borja to Terminal Terrestre de Guayaquil via Gran Terminal Terrestre Plaza Norte, Tumbes, and Tumbes in around 2d 19h.

Airlines
Bus operators

Want to know more about travelling around the world?

Rome2Rio's Travel Guide series provide vital information for the global traveller. Read our range of informative guides on popular transport routes and companies - including Getting to Rome from the airport, Italy Travel Guides, and Travelling to the UK: What do I need to know? - to help you get the most out of your next trip.

More Questions & Answers