There are 4 ways to get from Santiago to Santa Cruz by plane, bus, or car
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly
best- Fly from Comodoro Arturo Merino Benítez International Airport (SCL) to Viru Viru International Airport (VVI)plane SCL - VVI
6h 15m$173–553Bus
cheapest- Take the bus from Terminal Alameda - Turbus to Santa Cruzbus Santa Cruz
41h 9m$47–49Bus via Mendoza
- Take the bus from Terminal Sur de Santiago to Terminal Mendozabus Santiago
- Take the bus from Terminal Mendoza to Santa Cruzbus
39h 4m$117–194Drive 2,427.9 km
- Drive from Santiago to Santa Cruz de la Sierracar 2,427.9 km
31h 23m$300–433
Comodoro Arturo Merino Benítez International Airport (SCL) to Viru Viru International Airport (VVI) flights
Questions & Answers
The cheapest way to get from Santiago to Santa Cruz is to bus which costs $46 - $49 and takes 41h 9m.
The fastest way to get from Santiago to Santa Cruz is to fly which takes 6h 15m and costs $170 - $600.
No, there is no direct bus from Santiago to Santa Cruz. However, there are services departing from Terminal Sur de Santiago and arriving at Santa Cruz via Terminal Mendoza. The journey, including transfers, takes approximately 39h 4m.
The distance between Santiago and Santa Cruz is 1944 km. The road distance is 2427.9 km.
The best way to get from Santiago to Santa Cruz without a car is to bus via Mendoza which takes 39h 4m and costs $110 - $200.
It takes approximately 6h 15m to get from Santiago to Santa Cruz, including transfers.
Santiago to Santa Cruz bus services, operated by Andesmar, depart from Terminal Sur de Santiago station.
The best way to get from Santiago to Santa Cruz is to fly which takes 6h 15m and costs $170 - $600. Alternatively, you can bus via Mendoza, which costs $110 - $200 and takes 39h 4m.
Santiago to Santa Cruz bus services, operated by Andesmar, arrive at Terminal Mendoza station.
Yes, the driving distance between Santiago to Santa Cruz is 2428 km. It takes approximately 31h 23m to drive from Santiago to Santa Cruz.
What companies run services between Santiago, Chile and Santa Cruz, Bolivia?
Boliviana de Aviación and LATAM Chile fly from Comodoro Arturo Merino Benítez International Airport (SCL) to Viru Viru International Airport (VVI) 3 times a week. Alternatively, you can take a bus from Terminal Sur de Santiago to Santa Cruz de la Sierra via Terminal Mendoza and Santa Cruz in around 39h 4m.
- Website
- boa.bo
Flights from Comodoro Arturo Merino Benítez International Airport to Viru Viru International Airport
- Ave. Duration
- 3h 15m
- When
- Wednesday and Saturday
- Estimated price
- $160–470
- Website
- latam.com
Flights from Comodoro Arturo Merino Benítez International Airport to Viru Viru International Airport
- Ave. Duration
- 3h 20m
- When
- Wednesday
- Estimated price
- $220–550
- Phone
- 0810 122 1122
- [email protected]
- Website
- andesmar.com
Bus from Terminal Sur de Santiago to Terminal Mendoza
- Ave. Duration
- 7h
- Frequency
- 3 times a day
- Estimated price
- $15–41
- Schedules at
- andesmar.com
- Book at
- andesmar.com
- Bed
- $18–26
- Semi bed
- $15–21
- Phone
- 0800 122 2282
- [email protected]
- Website
- catainternacional.com
Bus from Terminal Sur de Santiago to Terminal Mendoza
- Ave. Duration
- 7h
- Frequency
- Twice daily
- Estimated price
- $18–44
- Website
- https://www.catainternacional.com/en
- Ejecutivo
- $23–35
- Semi Cama
- $18–26
- Ejecutivo Individual
- $26–35
- Phone
- +56 9 5950 0854
- [email protected]
- Website
- chiarinternacional.cl
Bus from Terminal Sur de Santiago to Terminal Mendoza
- Ave. Duration
- 6h
- Frequency
- Twice daily
- Estimated price
- $38
- Schedules at
- chiarinternacional.cl
- Phone
- +56 9 7242 8977
- [email protected]
- Website
- mathostour.cl
Bus from Terminal Sur de Santiago to Terminal Mendoza
- Ave. Duration
- 5h 30m
- Frequency
- Once daily
- Estimated price
- $38
- Schedules at
- mathostour.cl
- Book at
- kupos.cl
- Phone
- 0810 122 1122
- [email protected]
- Website
- andesmar.com
Bus from Terminal Sur de Santiago to Terminal Mendoza
- Ave. Duration
- 7h
- Frequency
- Twice a week
- Estimated price
- $34
- Schedules at
- andesmar.com
- Phone
- +59171291772
- Website
- grupoempresarialquirquincho.com
Bus from Terminal Mendoza to Santa Cruz
- Ave. Duration
- 31h
- Frequency
- Twice a week
- Estimated price
- $100–150
- Schedules at
- grupoempresarialquirquincho.com
- Phone
- +591 2527 7355
- [email protected]
- Website
- facebook.com
Bus from Terminal Alameda - Turbus to Santa Cruz
- Ave. Duration
- 40h
- Frequency
- 4 times a week
- Estimated price
- $44
- Schedules at
- facebook.com
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