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How to get fromSanto Domingo, Ecuador to Guayaquilby bus, car, or plane

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There are 4 ways to get from Santo Domingo, Ecuador to Guayaquil by bus, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Santo Domingo de los Colorados to Terminal Terrestre de Guayaquilbus bus Guayaquil / ...
    4h 53m
    $6–19

  2. Drive 270.9 km

    1. Drive from Santo Domingo, Ecuador to Guayaquilcar car 270.9 km
    4h 15m
    $16–23

  3. Bus, fly

    1. Take the bus from Santo Domingo de los Colorados to Quito Terminal Carcelénbus bus
    2. Fly from Mariscal Sucre International Airport (UIO) to José Joaquín De Olmedo International Airport (GYE)plane plane UIO - GYE
    4h 19m
    $94–161

  4. Bus via Santo Domingo de los Colorados

    1. Take the bus from Santo Domingo de los Colorados to Terminal Terrestre de Guayaquilbus bus Santo Domingo / ...
    6h 51m
    $9–21

Mariscal Sucre International Airport (UIO) to José Joaquín De Olmedo International Airport (GYE) flights

Calendar113Weekly Planes
Duration54 minAverage Duration
Ticket$32Cheapest Price
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Questions & Answers

Map of how to get from Santo Domingo, Ecuador to Guayaquil.ExpandLaunch map view
  • Distance: 268.3 km
  • Duration: 4h 53m

What companies run services between Santo Domingo, Ecuador and Guayaquil, Ecuador?

Trans Esmeraldas S.A. operates a bus from Santo Domingo de los Colorados to Terminal Terrestre de Guayaquil every 30 minutes. Tickets cost $12–19 and the journey takes 4h 53m. Three other operators also service this route.

Airlines
Bus operators

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