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How to get fromSanto Domingo, Ecuador to Machalaby bus, car, plane, or taxi

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There are 7 ways to get from Santo Domingo, Ecuador to Machala by bus, car, plane, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Santo Domingo de los Colorados to Terminal Terrestre de Guayaquilbus bus Guayaquil / ...
    2. Take the bus from Terminal Terrestre de Guayaquil to Machalabus bus Guayaquil / ...
    8h 18m
    $16–33

  2. Drive 410.1 km

    1. Drive from Santo Domingo, Ecuador to Machalacar car 410.1 km
    6h 13m
    $24–34

  3. Bus, fly to Santa Rosa Regional Airport

    1. Take the bus from Santo Domingo de los Colorados to Quito Terminal Carcelénbus bus
    2. Fly from Mariscal Sucre International Airport (UIO) to Santa Rosa Regional Airport (ETR)plane plane UIO - ETR
    3. Take the bus from Santa Rosa to Machalabus bus
    5h 17m
    $179–507

  4. Bus via Milagro

    1. Take the bus from Santo Domingo de los Colorados to Milagrobus bus Esmeraldas / ...
    2. Take the bus from Milagro to Machalabus bus Quevedo
    9h 30m
    $16–22

  5. Bus, fly to Cuenca

    1. Take the bus from Santo Domingo de los Colorados to Quito Terminal Carcelénbus bus
    2. Fly from Mariscal Sucre International Airport (UIO) to Cuenca (CUE)plane plane UIO - CUE
    3. Take the bus from Cuenca to Machalabus bus
    7h 39m
    $105–246

  6. Bus, fly to José Joaquín De Olmedo International Airport, taxi

    1. Take the bus from Santo Domingo de los Colorados to Quito Terminal Carcelénbus bus
    2. Fly from Mariscal Sucre International Airport (UIO) to José Joaquín De Olmedo International Airport (GYE)plane plane UIO - GYE
    3. Take the taxi from Guayaquil-Airport-GYE to Machalataxi taxi
    6h 54m
    $194–291

  7. Bus, fly to Loja

    1. Take the bus from Santo Domingo de los Colorados to Quito Terminal Carcelénbus bus
    2. Fly from Mariscal Sucre International Airport (UIO) to Loja (LOH)plane plane UIO - LOH
    3. Take the bus from Catamayo to Machalabus bus
    8h 57m
    $178–204

Mariscal Sucre International Airport (UIO) to Santa Rosa Regional Airport (ETR) flights

Calendar4Weekly Planes
Duration50 minAverage Duration
Ticket$163Cheapest Price
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Questions & Answers

Map of how to get from Santo Domingo, Ecuador to Machala.ExpandLaunch map view
  • Distance: 488.9 km
  • Duration: 8h 18m

What companies run services between Santo Domingo, Ecuador and Machala, Ecuador?

You can take a bus from Santo Domingo de los Colorados to Machala via Terminal Terrestre de Guayaquil in around 8h 18m.

Airlines
Bus operators
Other operators

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