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How to get fromSanto Domingo de los Colorados to Cuencaby bus, plane, or car

Find Transport to Cuenca

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There are 6 ways to get from Santo Domingo de los Colorados to Cuenca by bus, plane, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, fly

    best
    1. Take the bus from Santo Domingo de los Colorados to Quito Terminal Carcelénbus bus
    2. Fly from Mariscal Sucre International Airport (UIO) to Cuenca (CUE)plane plane UIO - CUE
    3h 53m
    $99–231

  2. Bus #2

    cheapest
    1. Take the bus from Santo Domingo de los Colorados to Terminal Terrestre de Guayaquilbus bus Santo Domingo / ...
    2. Take the bus from Terminal Terrestre de Guayaquil to Cuencabus bus Guayaquil / ...
    10h 6m
    $16–56

  3. Bus

    1. Take the bus from Santo Domingo de los Tsachilas to Puyobus bus Manta
    2. Take the bus from Puyo to Cuencabus bus Cuenca / ...
    6h 45m
    $19–43

  4. Drive 418.7 km

    1. Drive from Santo Domingo de los Colorados to Cuencacar car 418.7 km
    6h 40m
    $24–35

  5. Bus via Latacunga

    1. Take the bus from Santo Domingo de los Colorados to Latacungabus bus Esmeraldas
    2. Take the bus from Ambato to Cuencabus bus Loja
    8h 33m
    $24–52

  6. Bus via Riobamba

    1. Take the bus from Santo Domingo de los Colorados to Riobambabus bus Santo Domingo de los Colorados
    2. Take the bus from Riobamba to Cuencabus bus Riobamba
    11h 35m
    $17–38

Mariscal Sucre International Airport (UIO) to Cuenca (CUE) flights

Calendar38Weekly Planes
Duration1h 11mAverage Duration
Ticket$90Cheapest Price
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Questions & Answers

Map of how to get from Santo Domingo de los Colorados to Cuenca.ExpandLaunch map view
  • Distance: 505.5 km
  • Duration: 3h 53m

What companies run services between Santo Domingo de los Colorados, Ecuador and Cuenca, Ecuador?

You can take a bus from Santo Domingo de los Tsachilas to Cuenca via Puyo in around 6h 45m.

Airlines
Bus operators

Want to know more about travelling around the world?

Rome2Rio's Travel Guide series provide vital information for the global traveller. Read our range of informative guides on popular transport routes and companies - including How to get from Heathrow Airport into central London, How to get from London City Airport into central London, and How to get from Luton Airport into central London - to help you get the most out of your next trip.