How to get fromSanto Domingo de los Colorados to Cuenca, Ecuadorby bus, plane, or car

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There are 6 ways to get from Santo Domingo de los Colorados to Cuenca, Ecuador by bus, plane, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

Bus, fly
best
1. Take the bus from Santo Domingo de los Colorados to Quito Terminal Carcelénbus
2. Fly from Mariscal Sucre International Airport (UIO) to Cuenca (CUE)plane UIO - CUE
4h 2m
$94–221
Bus #2
cheapest
1. Take the bus from Santo Domingo de los Colorados to Terminal Terrestre de Guayaquilbus Santo Domingo / ...
2. Take the bus from Terminal Terrestre de Guayaquil to Cuencabus Guayaquil / ...
10h 6m
$16–56
Bus
1. Take the bus from Santo Domingo de los Tsachilas to Puyobus Manta
2. Take the bus from Puyo to Cuencabus Cuenca / ...
6h 45m
$19–43
Drive 419.9 km
1. Drive from Santo Domingo de los Colorados to Cuenca, Ecuadorcar 419.9 km
6h 40m
$24–35
Bus via Latacunga
1. Take the bus from Santo Domingo de los Colorados to Latacungabus Esmeraldas
2. Take the bus from Ambato to Cuencabus Loja
8h 33m
$24–53
Bus via Riobamba
1. Take the bus from Santo Domingo de los Colorados to Riobambabus Santo Domingo de los Colorados
2. Take the bus from Riobamba to Cuencabus Riobamba
11h 35m
$17–38

Mariscal Sucre International Airport (UIO) to Cuenca (CUE) flights

38Weekly Planes

1h 11mAverage Duration

$85Cheapest Price

Questions & Answers

Map of how to get from Santo Domingo de los Colorados to Cuenca, Ecuador.

Launch map view

Distance: 506.2 km
Duration: 4h 2m

What companies run services between Santo Domingo de los Colorados, Ecuador and Cuenca, Ecuador?

You can take a bus from Santo Domingo de los Tsachilas to Cuenca via Puyo in around 6h 45m.

Airlines

Bus operators

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Cuenca(opens in a new window), Ecuador(opens in a new window)

Cuenca, officially Santa Ana de los Ríos de Cuenca, is an Ecuadorian city, head of the canton of the same name and capital of the province of Azuay, as well as its largest and most populated city. It is crossed by the Tomebamba, Tarqui, Yanuncay and Machángara rivers, in the south-central inter-Andean region of Ecuador, in the Paute river basin, at an altitude of 2,538 meters above sea level and with a temperate Andean climate averaging 16.3 °C.

Places to stay in Cuenca

TRYP by Wyndham Cuenca Zahir(Opens in a new window)

8.9Fabulous

Mansion Alcazar(Opens in a new window)

9.0Fabulous

Four Points by Sheraton Cuenca(Opens in a new window)

9.2Superb

Villa Emilia Hostal(Opens in a new window)

9.5Superb

Rome2Rio makes travelling from Santo Domingo de los Colorados to Cuenca, Ecuador easy.

Rome2Rio is a door-to-door travel information and booking engine, helping you get to and from any location in the world. Find all the transport options for your trip from Santo Domingo de los Colorados to Cuenca, Ecuador right here. Rome2Rio displays up to date schedules, route maps, journey times and estimated fares from relevant transport operators, ensuring you can make an informed decision about which option will suit you best. Rome2Rio also offers online bookings for selected operators, making reservations easy and straightforward.