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How to get fromScranton to Buffalo Depew Stationby bus, train, car, plane, bus (Flixbus), or bus (Greyhound)

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There are 9 ways to get from Scranton to Buffalo Depew Station by bus, train, car, plane, bus (Flixbus), or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, train via Syracuse

    best
    1. Take the bus from Scranton to Syracuse Bus Stationbus bus FlixBus 2686 / ...
    2. Take the train from Syracuse Regional Transportation Center to Buffalo Depew Stationtrain train Empire Service / ...
    5h 57m
    $57–216

  2. Drive 231.6 mi

    cheapest
    1. Drive from Scranton to Buffalo Depew Stationcar car 231.6 mi
    4h 58m
    $43–62

  3. Fly from Wilkes-Barre/Scranton International Airport

    1. Fly from Wilkes-Barre/Scranton International Airport (AVP) to Buffalo Niagara International Airport (BUF)plane plane AVP - BUF
    4h 14m
    $173–813

  4. Bus, train

    1. Take the bus from Scranton, Pa to Rochester, Nybus bus 246
    2. Take the train from Rochester to Buffalo Depew Stationtrain train Lake Shore Limited / ...
    6h 25m
    $49–278

  5. Bus

    1. Take the bus from Scranton to Buffalobus bus FlixBus 2686 / ...
    8h 3m
    $52–82

  6. Bus via Scranton Bus Station

    1. Take the bus from Scranton Bus Station to Buffalobus bus Greyhound US0205 / ...
    8h 6m
    $72–97

  7. Bus to Newark Liberty International Airport, fly

    1. Take the bus from Scranton to Newark Penn Stationbus bus
    2. Fly from Newark Liberty International Airport (EWR) to Buffalo Niagara International Airport (BUF)plane plane EWR - BUF
    4h 55m
    $122–558

  8. Bus to John F. Kennedy International Airport, fly

    1. Take the bus from Scranton to New York Midtownbus bus
    2. Fly from John F. Kennedy International Airport (JFK) to Buffalo Niagara International Airport (BUF)plane plane JFK - BUF
    5h 48m
    $124–552

  9. Bus to Laguardia Airport, fly

    1. Take the bus from Scranton to Port Authority Bus Terminalbus bus
    2. Fly from Laguardia Airport (LGA) to Buffalo Niagara International Airport (BUF)plane plane LGA - BUF
    5h 53m
    $154–750

Scranton to Buffalo Depew Station by bus and train

Calendar42Weekly Services
Duration5h 57mAverage Duration
Ticket$57Cheapest Price
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Questions & Answers

Map of how to get from Scranton to Buffalo Depew Station.ExpandLaunch map view
  • Distance: 276.6 mi
  • Duration: 5h 57m

What companies run services between Scranton, PA, USA and Buffalo Depew Station, NY, USA?

United Airlines and American Airlines fly from Wilkes-Barre/Scranton International Airport (AVP) to Buffalo Niagara International Airport (BUF) 4 times a day. Alternatively, Jefferson Lines operates a bus from Scranton to Buffalo 5 times a day. Tickets cost $70–110 and the journey takes 5h 50m. Flixbus USA also services this route 3 times a day.

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