Rome2Rio

How to get fromSeattle to Florenceby plane, bus (Greyhound, Flixbus), train (Amtrak), car, or bus

Find Transport to Florence

See all options

There are 5 ways to get from Seattle to Florence by plane, bus (Greyhound, Flixbus), train (Amtrak), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Florence Regional Airport

    best
    1. Fly from Seattle-Tacoma International Airport (SEA) to Florence Regional Airport (FLO)plane plane SEA - FLO
    8h 55m
    $143–566

  2. Bus

    1. Take the bus from Seattle Bus Station to Denver Union Stationbus bus
    2. Take the bus from Denver Union Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to Florence Bus Stationbus bus
    2d 18h
    $528–817

  3. Train (Amtrak)

    1. Take the train from Seattle to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Raleigh Union Stationtrain train
    3. Take the train from Raleigh Union Station to Selma Stationtrain train
    4. Take the train from Selma Station to Florence Stationtrain train
    3d 4h
    $1,850–2,959

  4. Drive  2,856.9 mi

    1. Drive from Seattle to Florencecar car 2,856.9 mi
    47h 31m
    $522–754

  5. Fly to Myrtle Beach, bus

    1. Fly from Seattle-Tacoma International Airport (SEA) to Myrtle Beach (MYR)plane plane SEA - MYR
    2. Take the bus from Myrtle Beach Bus Station to Florence Bus Stationbus bus
    11h 17m
    $145–585

Seattle to Florence by bus

Calendar7Weekly Buses
Duration2d 18hAverage Duration
Ticket$528Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Seattle to Florence.ExpandLaunch map view
  • Distance: 2,387.6 mi
  • Duration: 8h 55m

What companies run services between Seattle, WA, USA and Florence, SC, USA?

American Airlines and Alaska Airlines, Inc. fly from Seattle-Tacoma International Airport (SEA) to Florence Regional Airport (FLO) every 4 hours. Alternatively, you can take a bus from Seattle Bus Station to Florence Bus Station via Denver Union Station, St Louis Bus Station, and Atlanta Bus Station in around 2d 18h.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Booking & Getting There