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How to get fromSeattle to Florenceby plane, bus (Greyhound, Flixbus), train (Amtrak), car, or bus

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There are 5 ways to get from Seattle to Florence by plane, bus (Greyhound, Flixbus), train (Amtrak), car, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Florence Regional Airport

    best
    1. Fly from Seattle-Tacoma International Airport (SEA) to Florence Regional Airport (FLO)plane plane SEA - FLO
    9h 46m
    $176–669

  2. Bus

    1. Take the bus from Seattle Bus Station to Denver Union Stationbus bus
    2. Take the bus from Denver Union Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Atlanta Bus Stationbus bus
    4. Take the bus from Atlanta Bus Station to Florence Bus Stationbus bus
    2d 17h
    $552–956

  3. Train (Amtrak)

    1. Take the train from Seattle to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to Raleigh Union Stationtrain train
    3. Take the train from Raleigh Union Station to Selma Stationtrain train
    4. Take the train from Selma Station to Florence Stationtrain train
    3d 4h
    $1,105–2,244

  4. Drive 2,856.9 mi

    1. Drive from Seattle to Florencecar car 2,856.9 mi
    47h 31m
    $522–754

  5. Fly to Myrtle Beach, bus

    1. Fly from Seattle-Tacoma International Airport (SEA) to Myrtle Beach (MYR)plane plane SEA - MYR
    2. Take the bus from Myrtle Beach to Florencebus bus
    11h 43m
    $196–624

Seattle to Florence by bus

Calendar7Weekly Buses
Duration2d 17hAverage Duration
Ticket$552Cheapest Price
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Questions & Answers

Map of how to get from Seattle to Florence.ExpandLaunch map view
  • Distance: 2,389 mi
  • Duration: 9h 46m

What companies run services between Seattle, WA, USA and Florence, SC, USA?

American Airlines and Alaska Airlines, Inc. fly from Seattle-Tacoma International Airport (SEA) to Florence Regional Airport (FLO) every 4 hours. Alternatively, you can take a bus from Seattle Bus Station to Florence Bus Station via Denver Union Station, St Louis Bus Station, and Atlanta Bus Station in around 2d 17h.

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