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How to get fromSeneca to Buffaloby taxi, plane, train, bus, car, or train (Amtrak)

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There are 7 ways to get from Seneca to Buffalo by taxi, plane, train, bus, car, or train (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Taxi to Greenville–Spartanburg International Airport, fly

    best
    1. Take the taxi from Seneca to Greenville–Spartanburg International Airport (GSP)taxi taxi
    2. Fly from Greenville–Spartanburg International Airport (GSP) to Buffalo Niagara International Airport (BUF)plane plane GSP - BUF
    5h 46m
    $284–997

  2. Drive to Asheville Regional Airport, fly

    cheapest
    1. Drive from Seneca to Asheville-Airport-AVLcar car
    2. Fly from Asheville Regional Airport (AVL) to Buffalo Niagara International Airport (BUF)plane plane AVL - BUF
    7h 4m
    $125–698

  3. Train, bus

    1. Take the train from Clemson Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train Crescent
    2. Take the bus from New York Midtown to Buffalobus bus FlixBus N2686 / ...
    26h 37m
    $335–639

  4. Taxi, bus

    1. Take the taxi from Seneca to Flying J - Commercetaxi taxi
    2. Take the bus from Flying J - Commerce to Atlantabus bus
    3. Take the bus from Atlanta Bus Station to Cleveland Bus Stationbus bus
    4. Take the bus from Cleveland Bus Station to Buffalobus bus
    27h 17m
    $305–574

  5. Drive 749.7 mi

    1. Drive from Seneca to Buffalocar car 749.7 mi
    13h 57m
    $137–198

  6. Taxi, bus to Hartsfield-Jackson Atlanta International Airport, fly

    1. Take the taxi from Seneca to Flying J - Commercetaxi taxi
    2. Take the bus from Flying J - Commerce to Atlantabus bus
    3. Fly from Hartsfield-Jackson Atlanta International Airport (ATL) to Buffalo Niagara International Airport (BUF)plane plane ATL - BUF
    7h 33m
    $297–1,093

  7. Train (Amtrak)

    1. Take the train from Clemson Amtrak Station to Ny Moynihan Train Hall At Penn Stationtrain train Crescent
    2. Take the train from Ny Moynihan Train Hall At Penn Station to Buffalotrain train Empire Service / ...
    26h 47m
    $405–809

Greenville–Spartanburg International Airport (GSP) to Buffalo Niagara International Airport (BUF) flights

Calendar113Weekly Planes
Duration4h 38mAverage Duration
Ticket$147Cheapest Price
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Questions & Answers

Map of how to get from Seneca to Buffalo.ExpandLaunch map view
  • Distance: 651.1 mi
  • Duration: 5h 46m

What companies run services between Seneca, SC, USA and Buffalo, NY, USA?

You can take a vehicle from Seneca to Buffalo via Clemson Amtrak Station and Ny Moynihan Train Hall At Penn Station in around 26h 47m.

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