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How to get fromSesto Calende to Sienaby bus, train, train (Trenitalia), car, or plane

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There are 6 ways to get from Sesto Calende to Siena by bus, train, train (Trenitalia), car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, train

    best
    1. Take the bus from Sesto Calende to Milano Centralebus bus Re4
    2. Take the train from Milano Centrale to Firenze S.M.N.train train Fr
    3. Take the bus from Firenze Autostazione to Siena-Via Tozzibus bus 131
    5h 7m

  2. Train

    cheapest
    1. Take the train from Sesto Calende to Rho-Fiera Milanotrain train Re
    2. Take the train from Milano Rogoredo to Bologna centraletrain train
    3. Take the train from Bologna Centrale to Firenze S.M.N.train train Fr
    4. Take the train from Firenze S.M.N. to Sienatrain train Re
    5h 42m
    €53–101

  3. Drive  417.7 km

    1. Drive from Sesto Calende to Sienacar car 417.7 km
    4h 14m
    €75–109

  4. Fly, train

    1. Fly from Milano Malpensa Airport (MXP) to Florence Peretola Airport (FLR)plane plane MXP - FLR
    2. Take the train from Firenze S.M.N. to Sienatrain train
    7h 45m
    €135–283

  5. Bus via Florence

    1. Take the bus from Sesto Calende to Milano Porta Garibaldibus bus R23
    2. Take the bus from Milano - Famagosta to Florence Villa Constanza Bus Stationbus bus
    3. Take the bus from Florence Villa Constanza Bus Station to Sienabus bus 443 / ...
    6h 43m

  6. Bus

    1. Take the bus from Sesto Calende to Rho Fiera Milanobus bus Re4 / ...
    2. Take the bus from Milano, Autostazione Lampugnano to Sienabus bus N528 / ...
    6h 45m

Milano Malpensa Airport (MXP) to Florence Peretola Airport (FLR) flights

Calendar45Weekly Planes
Duration5h 44mAverage Duration
Ticket€37Cheapest Price
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Comparing Your Travel Options

Map of how to get from Sesto Calende to Siena.ExpandLaunch map view
  • Distance: 438.8 km
  • Duration: 5h 7m

What companies run services between Sesto Calende, Italy and Siena, Italy?

You can take a train from Sesto Calende to Siena via Milano Rogoredo, Bologna Centrale, and Firenze S.M.N. in around 5h 42m. Alternatively, you can take a bus from Sesto Calende to Siena via Milan Porta Garibaldi, Garibaldi Fs, Famagosta, Milano - Famagosta, and Florence Villa Constanza Bus Station in around 6h 43m.

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