Rome2Rio

How to get fromSeymour to St. Louisby bus (Greyhound), car, plane, or bus

Find Transport to St. Louis

See all options

There are 5 ways to get from Seymour to St. Louis by bus (Greyhound), car, plane, or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from TA Travel Center - Seymour to Indianapolisbus bus Memphis
    2. Take the bus from Indianapolis Union Station to St Louis Bus Stationbus bus Greyhound US0421
    7h 27m
    $67–115

  2. Drive  252.9 mi

    cheapest
    1. Drive from Seymour to St. Louiscar car 252.9 mi
    5h 47m
    $47–67

  3. Drive to Covington, fly

    1. Drive from Seymour to Covington (CVG)car car
    2. Fly from Covington (CVG) to Lambert–St. Louis International Airport (STL)plane plane CVG - STL
    5h 48m
    $137–773

  4. Bus to Indianapolis, fly

    1. Take the bus from TA Travel Center - Seymour to Indianapolisbus bus
    2. Fly from Indianapolis (IND) to Lambert–St. Louis International Airport (STL)plane plane IND - STL
    8h 23m
    $892–955

  5. Bus to Louisville International Airport, fly

    1. Take the bus from TA Travel Center - Seymour to El Mercadito Grocery - Clarksville, INbus bus
    2. Fly from Louisville International Airport (SDF) to Lambert–St. Louis International Airport (STL)plane plane SDF - STL
    8h 31m
    $116–602

Covington (CVG) to Lambert–St. Louis International Airport (STL) flights

Calendar100Weekly Planes
Duration4h 8mAverage Duration
Ticket$121Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Seymour to St. Louis.ExpandLaunch map view
  • Distance: 323.6 mi
  • Duration: 7h 27m

What companies run services between Seymour, IN, USA and St. Louis, MO, USA?

You can take a vehicle from Seymour to St Louis Bus Station via TA Travel Center - Seymour, Indianapolis, Lafayette Rd & Office Plaza Blvd, Ctc-R, and Indianapolis Union Station in around 7h 27m.

Airlines
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Booking & Getting There