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How to get fromSheboygan to Mayo Clinicby bus (Greyhound), car, bus, or plane

Find Transport to Mayo Clinic

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There are 6 ways to get from Sheboygan to Mayo Clinic by bus (Greyhound), car, bus, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Sheboygan Transit to Milwaukeebus bus 1490 / ...
    2. Take the bus from Milwaukee to Rochesterbus bus Jefferson Lines 966
    7h 58m
    $79–113

  2. Drive  258.9 mi

    cheapest
    1. Drive from Sheboygan to Mayo Cliniccar car 258.9 mi
    5h 5m
    $48–69

  3. Bus to General Mitchell International Airport, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the bus from Sheboygan Transit to Milwaukeebus bus
    2. Fly from General Mitchell International Airport (MKE) to Minneapolis–Saint Paul International Airport (MSP)plane plane MKE - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 55m
    $663–1,079

  4. Bus via La Crosse

    1. Take the bus from Sheboygan Transit to Green Bay, WI - Transitbus bus
    2. Take the bus from Green Bay station to La Crosse Grand River Stationbus bus
    3. Take the bus from La Crosse to Rochesterbus bus
    10h 33m
    $77–99

  5. Bus to Green Bay, fly to Minneapolis–Saint Paul International Airport, bus

    1. Take the bus from Sheboygan Transit to Green Bay, WI - Transitbus bus
    2. Fly from Green Bay (GRB) to Minneapolis–Saint Paul International Airport (MSP)plane plane GRB - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 44m
    $152–502

  6. Bus, bus to Chicago O'Hare International Airport, fly to Rochester

    1. Take the bus from Sheboygan Transit to Milwaukeebus bus
    2. Take the bus from Milwaukee Intermodal/Amtrak Station to O'Hare International Airport - Terminal 2 Departuresbus bus
    3. Fly from Chicago O'Hare International Airport (ORD) to Rochester (RST)plane plane ORD - RST
    7h 30m
    $88–375

Sheboygan to Mayo Clinic by bus and foot

Calendar7Weekly Services
Duration7h 58mAverage Duration
Ticket$79Cheapest Price
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Comparing Your Travel Options

Map of how to get from Sheboygan to Mayo Clinic.ExpandLaunch map view
  • Distance: 333.1 mi
  • Duration: 7h 58m

What companies run services between Sheboygan, WI, USA and Mayo Clinic, MN, USA?

You can take a bus from Sheboygan Transit to Mayo Clinic via Milwaukee and Rochester in around 7h 58m.

Airlines
Bus operators

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