There are 3 ways to get from Shepherdsville to Knoxville by car or plane
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Drive 217.7 mi
best- Drive from Shepherdsville to Knoxvillecar 217.7 mi
4h 20m$40–58Fly from Louisville International Airport
- Fly from Louisville International Airport (SDF) to Mcghee Tyson Airport (TYS)plane SDF - TYS
3h 25m$244–1,127Drive to Blue Grass Airport, fly
- Drive from Shepherdsville to Lexington-Airport-LEXcar
- Fly from Blue Grass Airport (LEX) to Mcghee Tyson Airport (TYS)plane LEX - TYS
5h 8m$208–989
Louisville International Airport (SDF) to Mcghee Tyson Airport (TYS) flights
Comparing Your Travel Options
The cheapest way to get from Shepherdsville to Knoxville is to drive which costs $35 - $60 and takes 4h 20m.
The fastest way to get from Shepherdsville to Knoxville is to fly which takes 3h 25m and costs $240 - $1,200.
The distance between Shepherdsville and Knoxville is 219 miles. The road distance is 219 miles.
It takes approximately 4h 20m to drive 219 miles from Shepherdsville to Knoxville.
Yes, the driving distance between Shepherdsville to Knoxville is 219 miles. It takes approximately 4h 20m to drive from Shepherdsville to Knoxville.
There are 318+ hotels available in Knoxville.
What companies run services between Shepherdsville, KY, USA and Knoxville, TN, USA?
Southwest Airlines, Delta, and American Airlines fly from Louisville International Airport (SDF) to Mcghee Tyson Airport (TYS) every 2 hours.
- Website
- aa.com
Flights from Louisville International Airport to Mcghee Tyson Airport via Charlotte
- Ave. Duration
- 4h 5m
- When
- Thursday, Friday, Sunday, Monday, Wednesday, and Saturday
- Estimated price
- $180–1,100
Flights from Blue Grass Airport to Mcghee Tyson Airport via Charlotte
- Ave. Duration
- 3h 56m
- When
- Every day
- Estimated price
- $140–900
Flights from Blue Grass Airport to Mcghee Tyson Airport via Chicago O'Hare
- Ave. Duration
- 5h 3m
- When
- Every day
- Estimated price
- $190–1,100
- Website
- delta.com
Flights from Louisville International Airport to Mcghee Tyson Airport via Atlanta
- Ave. Duration
- 3h 43m
- When
- Every day
- Estimated price
- $170–1,100
Flights from Louisville International Airport to Mcghee Tyson Airport via Detroit
- Ave. Duration
- 4h 38m
- When
- Tuesday, Wednesday, Monday, Thursday, Friday, and Sunday
- Estimated price
- $220–1,300
Flights from Blue Grass Airport to Mcghee Tyson Airport via Atlanta
- Ave. Duration
- 3h 46m
- When
- Every day
- Estimated price
- $140–900
Flights from Blue Grass Airport to Mcghee Tyson Airport via Detroit
- Ave. Duration
- 6h 20m
- When
- Tuesday and Wednesday
- Estimated price
- $180–1,000
- Website
- southwest.com
Flights from Louisville International Airport to Mcghee Tyson Airport via Nashville
- Ave. Duration
- 3h 49m
- When
- Every day
- Estimated price
- $140–1,000
Flights from Louisville International Airport to Mcghee Tyson Airport via Baltimore
- Ave. Duration
- 4h 25m
- When
- Monday, Thursday, and Friday
- Estimated price
- $260–1,400
- Website
- united.com
Flights from Blue Grass Airport to Mcghee Tyson Airport via Chicago O'Hare
- Ave. Duration
- 5h 56m
- When
- Every day
- Estimated price
- $190–1,100
- Website
- allegiantair.com
Flights from Blue Grass Airport to Mcghee Tyson Airport via Orlando Sanford
- Ave. Duration
- 7h 32m
- When
- Tuesday
- Estimated price
- $250–1,200
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