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How to get fromSherman Oaks to La Mesaby train (Amtrak), bus, car, plane, tram, or bus (Flixbus)

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There are 6 ways to get from Sherman Oaks to La Mesa by train (Amtrak), bus, car, plane, tram, or bus (Flixbus)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train via Union Station - Metro B & D Lines (Amtrak)

    best
    1. Take the train from Los Angeles to San Diego Old Town Transportation Centertrain train Pacific Surfliner
    5h 11m
    $41–103

  2. Drive 138.3 mi

    cheapest
    1. Drive from Sherman Oaks to La Mesacar car 138.3 mi
    2h 27m
    $26–37

  3. Line 237 bus, bus, line 10 bus

    1. Take the bus from Burbank / Van Nuys to Woodley / Saticoybus bus 237
    2. Take the bus from Van Nuys FlyAway Terminal - 7610 Woodley Ave to LAX Tom Bradley International Terminalbus bus
    3. Take the bus from LAX Terminal 3 Shared Rides Stop to San Diegobus bus
    4. Take the bus from Old Town Transit Center to University Av & College Avbus bus 10
    6h 34m
    $68–135

  4. Line 237 bus, fly, tram

    1. Take the bus from Burbank / Van Nuys to Woodley / Saticoybus bus
    2. Fly from Los Angeles International Airport (LAX) to San Diego International Airport (SAN)plane plane LAX - SAN
    3. Take the tram from Civic Center Station to La Mesa Blvd Stationtram tram
    4h 42m
    $173–685

  5. Train (Amtrak)

    1. Take the train from Van Nuys to San Diegotrain train Pacific Surfliner
    6h 14m
    $49–117

  6. Bus (Flixbus)

    1. Take the bus from Los Angeles Downtown to San Diegobus bus FlixBus 2006 / ...
    6h 35m
    $26–53

Sherman Oaks to La Mesa by bus, subway, train, and tram (Amtrak)

Calendar91Weekly Services
Duration5h 11mAverage Duration
Ticket$41Cheapest Price
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Questions & Answers

Map of how to get from Sherman Oaks to La Mesa.ExpandLaunch map view
  • Distance: 152.8 mi
  • Duration: 5h 11m

What companies run services between Sherman Oaks, CA, USA and La Mesa, CA, USA?

Amtrak operates a train from Los Angeles to San Diego Old Town Transportation Center hourly. Tickets cost $35–85 and the journey takes 2h 42m. Alternatively, you can take a bus from Burbank / Van Nuys to University Av & Allison Av via Woodley / Saticoy, Van Nuys FlyAway Terminal - 7610 Woodley Ave, LAX Tom Bradley International Terminal, LAX Terminal 3 Shared Rides Stop, San Diego, Old Town Transit Center, and University Av & College Av in around 6h 34m.

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