There are 12 ways to get from Sicily to Isernia by plane, train, ferry, car, bus, or train (Trenitalia)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Vincenzo Magliocco Airport to Fiumicino International Airport, train
best- Fly from Vincenzo Magliocco Airport (CIY) to Fiumicino International Airport (FCO)plane CIY - FCO
- Take the train from Roma Termini to Iserniatrain
5h 15m€87–357Bus via Caserta
cheapest- Take the bus from Palermo Terminal Bus to Caserta pzza Garibaldibus Autoservizi Salemi S202
- Take the bus from Caserta Terminal Bus to Iserniabus 433
13h 24m€37–56Ferry, drive
- Take the ferry from Port of Palermo to Naples Beverelloferry
- Drive from Naples Beverello to Iserniacar
10h 5m€48–96Train, ferry
- Take the train from Palermo Centrale to Messina Centraletrain Re
- Take the ferry from Messina Marittima to Villa S.Giovanniferry M1 / ...
- Take the train from Villa S.Giovanni to Napoli Afragolatrain Fr
- Take the train from Napoli Afragola to Iserniatrain Re
12h 24mFly Catania–Fontanarossa Airport to Naples Airport, train
- Fly from Catania–Fontanarossa Airport (CTA) to Naples Airport (NAP)plane CTA - NAP
- Take the train from Caserta to Iserniatrain
5h 58m€42–193Fly Palermo Airport to Naples Airport, train
- Fly from Palermo Airport (PMO) to Naples Airport (NAP)plane PMO - NAP
- Take the train from Caserta to Iserniatrain
6h 25m€38–194Fly Catania–Fontanarossa Airport to Fiumicino International Airport, train
- Fly from Catania–Fontanarossa Airport (CTA) to Fiumicino International Airport (FCO)plane CTA - FCO
- Take the train from Roma Termini to Iserniatrain
6h 7m€52–155Fly Palermo Airport to Fiumicino International Airport, train
- Fly from Palermo Airport (PMO) to Fiumicino International Airport (FCO)plane PMO - FCO
- Take the train from Roma Termini to Iserniatrain
6h 39m€47–166Fly Trapani Airport to Fiumicino International Airport, train
- Fly from Trapani Airport (TPS) to Fiumicino International Airport (FCO)plane TPS - FCO
- Take the train from Roma Termini to Iserniatrain
6h 25m€68–274Fly Catania–Fontanarossa Airport to Abruzzo Airport, bus
- Fly from Catania–Fontanarossa Airport (CTA) to Abruzzo Airport (PSR)plane CTA - PSR
- Take the bus from Pescara Airport to San Salvo Marinabus
- Take the bus from San Salvo Marina to Iserniabus
7h 2m€46–195Train (Trenitalia)
- Take the train from Palermo Centrale to Napoli Centraletrain Ic
- Take the train from Napoli Centrale to Iserniatrain Re
13h 28m€81–153Bus
- Take the bus from Palermo Piazza Cairoli to Casello - A1 Ingresso Caianellobus
- Take the bus from Casello - A1 Ingresso Caianello to Iserniabus 6
19h 19m€173–244
Vincenzo Magliocco Airport (CIY) to Fiumicino International Airport (FCO) flights
Comparing Your Travel Options
The cheapest way to get from Sicily to Isernia is to bus via Caserta which costs €35 - €60 and takes 13h 24m.
The fastest way to get from Sicily to Isernia is to fly and train which takes 5h 15m and costs €85 - €360.
No, there is no direct bus from Sicily to Isernia. However, there are services departing from Piazza Boiardo and arriving at Isernia via Palermo Terminal Bus and Caserta Terminal Bus. The journey, including transfers, takes approximately 13h 24m.
No, there is no direct train from Sicily to Isernia. However, there are services departing from Palermo Notarbartolo and arriving at Isernia via Palermo Centrale and Napoli Centrale. The journey, including transfers, takes approximately 13h 28m.
The distance between Sicily and Isernia is 801 km.
The best way to get from Sicily to Isernia without a car is to train and ferry which takes 12h 24m and costs .
It takes approximately 5h 15m to get from Sicily to Isernia, including transfers.
Sicily to Isernia bus services, operated by Autoservizi Salemi Srl, depart from Palermo Terminal Bus station.
Sicily to Isernia train services, operated by Trenitalia Intercity, depart from Palermo Centrale station.
The best way to get from Sicily to Isernia is to bus via Caserta which takes 13h 24m and costs €35 - €60. Alternatively, you can train, which costs €80 - €160 and takes 13h 28m.
What companies run services between Sicily, Italy and Isernia, Italy?
You can take a bus from Piazza Boiardo to Isernia via Stazione Centrale Pensilina Esterna, Palermo Terminal Bus, Caserta pzza Garibaldi, and Caserta Terminal Bus in around 13h 24m. Alternatively, you can take a train from Palermo Notarbartolo to Isernia via Palermo Centrale and Napoli Centrale in around 13h 28m.
- Website
- ryanair.com
Flights from Catania–Fontanarossa Airport to Naples Airport
- Ave. Duration
- 1h 10m
- When
- Every day
- Estimated price
- €26–160
Flights from Palermo Airport to Naples Airport
- Ave. Duration
- 1h
- When
- Every day
- Estimated price
- €27–230
Flights from Catania–Fontanarossa Airport to Fiumicino International Airport
- Ave. Duration
- 1h 30m
- When
- Every day
- Estimated price
- €22–80
Flights from Catania–Fontanarossa Airport to Fiumicino International Airport via Bari
- Ave. Duration
- 2h 45m
- When
- Saturday
- Estimated price
- €22–80
Flights from Palermo Airport to Fiumicino International Airport
- Ave. Duration
- 1h 15m
- When
- Every day
- Estimated price
- €22–130
Flights from Trapani Airport to Fiumicino International Airport
- Ave. Duration
- 1h 15m
- When
- Every day
- Estimated price
- €35–230
Flights from Catania–Fontanarossa Airport to Abruzzo Airport
- Ave. Duration
- 1h 25m
- When
- Friday to Thursday
- Estimated price
- €35–170
- Phone
- +39.06.5210550
- Website
- Trenitalia
Train from Roma Termini to Isernia
- Ave. Duration
- 2h 8m
- Frequency
- Every 3 hours
- Estimated price
- €22–35
- Website
- Trenitalia
Train from Palermo Centrale to Messina Centrale
- Ave. Duration
- 2h 54m
- Frequency
- Hourly
- Estimated price
- €26–40
- Website
- Trenitalia
Train from Napoli Afragola to Isernia
- Ave. Duration
- 1h 49m
- Frequency
- Every 4 hours
- Estimated price
- €14–20
- Website
- Trenitalia
Train from Caserta to Isernia
- Ave. Duration
- 1h 17m
- Frequency
- Every 3 hours
- Estimated price
- €10–15
- Website
- Trenitalia
Train from Caserta to Isernia
- Ave. Duration
- 1h 17m
- Frequency
- Every 3 hours
- Estimated price
- €10–15
- Website
- Trenitalia
Train from Roma Termini to Isernia
- Ave. Duration
- 2h 8m
- Frequency
- Every 3 hours
- Estimated price
- €22–35
- Website
- Trenitalia
Train from Roma Termini to Isernia
- Ave. Duration
- 2h 8m
- Frequency
- Every 3 hours
- Estimated price
- €22–35
- Website
- Trenitalia
Train from Roma Termini to Isernia
- Ave. Duration
- 2h 8m
- Frequency
- Every 3 hours
- Estimated price
- €22–35
- Website
- Trenitalia
Train from Napoli Centrale to Isernia
- Ave. Duration
- 2h 5m
- Frequency
- Every 4 hours
- Estimated price
- €15–22
- Website
- Trenitalia
- Phone
- (+39) 0923 98.11.20
- Website
- autoservizisalemi.it
Bus from Palermo Terminal Bus to Caserta pzza Garibaldi
- Ave. Duration
- 9h 50m
- Frequency
- Twice daily
- Estimated price
- €30–45
- Schedules at
- autoservizisalemi.it
- Phone
- +39.081.496.444
- [email protected]
- Website
- Grimaldi Lines
Ferry from Port of Palermo to Naples Beverello
- Ave. Duration
- 8h 30m
- Frequency
- 6 times a week
- Estimated price
- €30–70
- Website
- Grimaldi Lines
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Booking & Getting There
Sicily to Isernia bus services, operated by Autoservizi Salemi Srl, arrive at Caserta pzza Garibaldi station.
Sicily to Isernia train services, operated by Trenitalia Intercity, arrive at Napoli Centrale station.
Book your Sicily to Isernia train tickets online with Omio.
There are 452+ hotels available in Isernia.








