There are 9 ways to get from Sicily to Isernia by plane, train, ferry, car, train (Trenitalia), or bus
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly Vincenzo Magliocco Airport to Fiumicino International Airport, train
best- Fly from Vincenzo Magliocco Airport (CIY) to Fiumicino International Airport (FCO)plane CIY - FCO
- Take the train from Roma Termini to Iserniatrain
5h 20m€82–377Fly Palermo Airport to Naples Airport, train
cheapest- Fly from Palermo Airport (PMO) to Naples Airport (NAP)plane PMO - NAP
- Take the train from Caserta to Iserniatrain
6h 25m€36–204Ferry, drive
- Take the ferry from Port of Palermo to Naples Beverelloferry
- Drive from Naples Beverello to Iserniacar
10h 5m€48–97Train (Trenitalia)
- Take the train from Palermo Centrale to Casertatrain Ic
- Take the train from Caserta to Iserniatrain Re
12h 46m€81–146Bus via Caserta
- Take the bus from Palermo Terminal Bus to Caserta pzza Garibaldibus Autoservizi Salemi S202
- Take the bus from Caserta Terminal Bus to Iserniabus 433
13h 35m€38–57Fly Catania–Fontanarossa Airport to Fiumicino International Airport, train
- Fly from Catania–Fontanarossa Airport (CTA) to Fiumicino International Airport (FCO)plane CTA - FCO
- Take the train from Roma Termini to Iserniatrain
6h 16m€51–155Fly Palermo Airport to Fiumicino International Airport, train
- Fly from Palermo Airport (PMO) to Fiumicino International Airport (FCO)plane PMO - FCO
- Take the train from Roma Termini to Iserniatrain
6h 44m€47–166Fly Catania–Fontanarossa Airport to Naples Airport, train
- Fly from Catania–Fontanarossa Airport (CTA) to Naples Airport (NAP)plane CTA - NAP
- Take the train from Caserta to Iserniatrain
5h 53m€40–193Bus
- Take the bus from Palermo to Caserta - Casagiovebus N592
- Take the bus from Caserta - Casagiove to Iserniabus 558
15h 29m€77–122
Sicily to Isernia by train (Trenitalia)
Comparing Your Travel Options
The cheapest way to get from Sicily to Isernia is to bus via Caserta which costs €35 - €60 and takes 13h 35m.
The fastest way to get from Sicily to Isernia is to fly and train which takes 5h 20m and costs €80 - €380.
No, there is no direct bus from Sicily to Isernia. However, there are services departing from Piazza Boiardo and arriving at Isernia via Palermo Terminal Bus and Caserta Terminal Bus. The journey, including transfers, takes approximately 13h 35m.
No, there is no direct train from Sicily to Isernia. However, there are services departing from Palermo Notarbartolo and arriving at Isernia via Palermo Centrale and Caserta. The journey, including transfers, takes approximately 12h 46m.
The distance between Sicily and Isernia is 801 km.
The best way to get from Sicily to Isernia without a car is to train which takes 12h 46m and costs €80 - €150.
It takes approximately 5h 20m to get from Sicily to Isernia, including transfers.
Sicily to Isernia bus services, operated by Autoservizi Salemi Srl, depart from Palermo Terminal Bus station.
Sicily to Isernia train services, operated by Trenitalia Intercity, depart from Palermo Centrale station.
The best way to get from Sicily to Isernia is to train which takes 12h 46m and costs €80 - €150. Alternatively, you can bus via Caserta, which costs €35 - €60 and takes 13h 35m.
What companies run services between Sicily, Italy and Isernia, Italy?
You can take a train from Palermo Notarbartolo to Isernia via Palermo Centrale and Caserta in around 12h 46m. Alternatively, you can take a bus from Piazza Boiardo to Isernia via Stazione Centrale Pensilina Esterna, Palermo Terminal Bus, Caserta pzza Garibaldi, and Caserta Terminal Bus in around 13h 35m.
- Website
- ryanair.com
Flights from Catania–Fontanarossa Airport to Fiumicino International Airport
- Ave. Duration
- 1h 24m
- When
- Every day
- Estimated price
- €21–100
Flights from Palermo Airport to Fiumicino International Airport
- Ave. Duration
- 1h 14m
- When
- Every day
- Estimated price
- €22–110
Flights from Palermo Airport to Naples Airport
- Ave. Duration
- 1h
- When
- Saturday
- Estimated price
- €28–250
Flights from Catania–Fontanarossa Airport to Naples Airport
- Ave. Duration
- 1h 10m
- When
- Saturday
- Estimated price
- €27–170
- Website
- ita-airways.com
Flights from Catania–Fontanarossa Airport to Fiumicino International Airport
- Ave. Duration
- 1h 25m
- When
- Every day
- Estimated price
- €45–110
Flights from Palermo Airport to Fiumicino International Airport
- Ave. Duration
- 1h 12m
- When
- Every day
- Estimated price
- €45–190
- Website
- aeroitalia.com
Flights from Vincenzo Magliocco Airport to Fiumicino International Airport
- Ave. Duration
- 1h 15m
- When
- Every day
- Estimated price
- €35–270
Flights from Catania–Fontanarossa Airport to Fiumicino International Airport
- Ave. Duration
- 1h 25m
- When
- Every day
- Estimated price
- €21–100
Flights from Palermo Airport to Fiumicino International Airport
- Ave. Duration
- 1h 10m
- When
- Every day
- Estimated price
- €16–120
- Website
- volotea.com
Flights from Catania–Fontanarossa Airport to Fiumicino International Airport
- Ave. Duration
- 1h 25m
- When
- Every day
- Estimated price
- €45–110
Flights from Palermo Airport to Fiumicino International Airport
- Ave. Duration
- 1h 12m
- When
- Every day
- Estimated price
- €45–190
Flights from Palermo Airport to Naples Airport
- Ave. Duration
- 1h
- When
- Sunday
- Estimated price
- €12–95
- Website
- flyulendo.com
Flights from Catania–Fontanarossa Airport to Fiumicino International Airport
- Ave. Duration
- 1h 30m
- When
- Every day
- Estimated price
- €22–110
Flights from Palermo Airport to Fiumicino International Airport
- Ave. Duration
- 1h 10m
- When
- Every day
- Estimated price
- €18–80
- Website
- easyjet.com
Flights from Palermo Airport to Naples Airport
- Ave. Duration
- 55 min
- When
- Wednesday, Thursday, and Saturday
- Estimated price
- €23–150
Flights from Catania–Fontanarossa Airport to Naples Airport
- Ave. Duration
- 1h 7m
- When
- Saturday
- Estimated price
- €20–130
- Phone
- +39.06.5210550
- Website
- Trenitalia
Train from Roma Termini to Isernia
- Ave. Duration
- 2h 8m
- Frequency
- 5 times a day
- Estimated price
- €22–35
- Website
- Trenitalia
Train from Caserta to Isernia
- Ave. Duration
- 1h 17m
- Frequency
- 5 times a day
- Estimated price
- €10–15
- Website
- Trenitalia
Train from Roma Termini to Isernia
- Ave. Duration
- 2h 8m
- Frequency
- 5 times a day
- Estimated price
- €22–35
- Website
- Trenitalia
Train from Roma Termini to Isernia
- Ave. Duration
- 2h 8m
- Frequency
- 5 times a day
- Estimated price
- €22–35
- Website
- Trenitalia
Train from Caserta to Isernia
- Ave. Duration
- 1h 17m
- Frequency
- 5 times a day
- Estimated price
- €10–15
- Website
- Trenitalia
Train from Caserta to Isernia
- Ave. Duration
- 1h 17m
- Frequency
- 5 times a day
- Estimated price
- €10–15
- Website
- Trenitalia
- Phone
- +39 06 68475475
- Website
- Trenitalia Intercity
Train from Palermo Centrale to Caserta
- Ave. Duration
- 9h 12m
- Frequency
- Once a week
- Estimated price
- €70–130
- Website
- Trenitalia Intercity
- Phone
- (+39) 0923 98.11.20
- Website
- autoservizisalemi.it
Bus from Palermo Terminal Bus to Caserta pzza Garibaldi
- Ave. Duration
- 9h 50m
- Frequency
- Twice daily
- Estimated price
- €30–45
- Schedules at
- autoservizisalemi.it
- Phone
- +49 30 300 137 300
- [email protected]
- Website
- Flixbus
Bus from Caserta Terminal Bus to Isernia
- Ave. Duration
- 1h 25m
- Frequency
- Once daily
- Estimated price
- €7–11
- Website
- Flixbus
Bus from Palermo to Caserta - Casagiove
- Ave. Duration
- 11h 55m
- Frequency
- 5 times a week
- Estimated price
- €70–110
- Website
- Flixbus
Bus from Caserta - Casagiove to Isernia
- Ave. Duration
- 1h 14m
- Frequency
- Once daily
- Estimated price
- €6–11
- Website
- Flixbus
- Phone
- +39.081.496.444
- [email protected]
- Website
- Grimaldi Lines
Ferry from Port of Palermo to Naples Beverello
- Ave. Duration
- 8h 30m
- Frequency
- 6 times a week
- Estimated price
- €30–70
- Website
- Grimaldi Lines
Want to know more about travelling around Italy
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Italy Travel Guides
Read the travel guide
Getting to Rome from the airport
Read the travel guide
Travelling by boat in Italy
Read the travel guide
Booking & Getting There
Sicily to Isernia bus services, operated by Autoservizi Salemi Srl, arrive at Caserta pzza Garibaldi station.
Sicily to Isernia train services, operated by Trenitalia Intercity, arrive at Caserta station.
Book your Sicily to Isernia train tickets online with Omio.
There are 461+ hotels available in Isernia.















