There are 11 ways to get from Siena to Karlsruhe by train (Trenitalia), bus, car, train, or plane
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train
best- Take the train from Siena to Firenze S.M.N.train Re
- Take the train from Firenze S.M.N. to Milano Centraletrain Fr
- Take the train from Milano Centrale to Karlsruhe Hbftrain Ec
11h 7m€152–278Bus via Karlsruhe central train station
cheapest- Take the bus from Siena to Florence Villa Constanza Bus Stationbus 1509 / ...
- Take the bus from Florence Villa Constanza Bus Station to Karlsruhe central train stationbus N77
17h€70–118Bus
- Take the bus from Siena to Florence Villa Constanza Bus Stationbus 1509 / ...
- Take the bus from Florence Villa Constanza Bus Station to Karlsruhe Central Bus Stationbus
13h 7m€115–168Drive 890.1 km
- Drive from Siena to Karlsruhecar 890.1 km
8h 47m€141–203Train to Florence Peretola Airport, fly to Stuttgart Airport, train
- Take the train from Siena to Firenze S.M.N.train
- Fly from Florence Peretola Airport (FLR) to Stuttgart Airport (STR)plane FLR - STR
- Take the train from Stuttgart Hbf to Karlsruhe Hbftrain
8h 34m€132–367Train via Basel
- Take the train from Siena to Firenze S.M.N.train Re
- Take the train from Firenze S.M.N. to Milano Centraletrain Fr
- Take the train from Milano Centrale to Basel Sbbtrain Ec
- Take the train from Basel SBB to Karlsruhe Hauptbahnhoftrain 12 / ...
11h 21m€152–378Train to Florence Peretola Airport, fly to Frankfurt, train
- Take the train from Siena to Firenze S.M.N.train
- Fly from Florence Peretola Airport (FLR) to Frankfurt (FRA)plane FLR - FRA
- Take the train from Frankfurt to Karlsruhe Hauptbahnhoftrain
7h 45m€148–385Train, train to Pisa International Airport, fly to Frankfurt
- Take the train from Siena to Empolitrain
- Take the train from Empoli to Pisa Centraletrain
- Fly from Pisa International Airport (PSA) to Frankfurt (FRA)plane PSA - FRA
- Take the train from Frankfurt to Karlsruhe Hauptbahnhoftrain
7h 53m€132–364Train, train to Bologna Guglielmo Marconi Airport, fly to Frankfurt
- Take the train from Siena to Firenze S.M.N.train
- Take the train from Firenze S.M.N. to Bologna Centraletrain
- Fly from Bologna Guglielmo Marconi Airport (BLQ) to Frankfurt (FRA)plane BLQ - FRA
- Take the train from Frankfurt to Karlsruhe Hauptbahnhoftrain
8h 14m€131–423Train to Florence Peretola Airport, fly to Zurich Airport, train
- Take the train from Siena to Firenze S.M.N.train
- Fly from Florence Peretola Airport (FLR) to Zurich Airport (ZRH)plane FLR - ZRH
- Take the train from Zürich HB to Basel SBBtrain
- Take the train from Basel SBB to Karlsruhe Hauptbahnhoftrain
9h 3m€182–521Train to Florence Peretola Airport, fly to Munich International Airport, train
- Take the train from Siena to Firenze S.M.N.train
- Fly from Florence Peretola Airport (FLR) to Munich International Airport (MUC)plane FLR - MUC
- Take the train from München Hbf to Hauptbahnhoftrain
- Take the train from Stuttgart Hbf to Karlsruhe Hbftrain
9h 28m€172–533
Siena to Karlsruhe by train
Questions & Answers
The cheapest way to get from Siena to Karlsruhe is to bus via Karlsruhe central train station which costs €70 - €120 and takes 17h.
The fastest way to get from Siena to Karlsruhe is to train and fly which takes 7h 45m and costs €140 - €390.
No, there is no direct bus from Siena to Karlsruhe station. However, there are services departing from Siena and arriving at Karlsruhe Central Bus Station via Florence Villa Constanza Bus Station. The journey, including transfers, takes approximately 13h 7m.
No, there is no direct train from Siena to Karlsruhe. However, there are services departing from Siena and arriving at Karlsruhe Hbf via Firenze S.M.N. and Milano Centrale. The journey, including transfers, takes approximately 11h 7m.
The distance between Siena and Karlsruhe is 928 km. The road distance is 890.1 km.
The best way to get from Siena to Karlsruhe without a car is to train which takes 11h 7m and costs €150 - €280.
It takes approximately 11h 7m to get from Siena to Karlsruhe, including transfers.
Siena to Karlsruhe bus services, operated by FlixBus, depart from Siena station.
Siena to Karlsruhe train services, operated by Trenitalia, depart from Siena station.
The best way to get from Siena to Karlsruhe is to train which takes 11h 7m and costs €150 - €280. Alternatively, you can bus, which costs €110 - €170 and takes 13h 7m.
What companies run services between Siena, Italy and Karlsruhe, Germany?
You can take a train from Siena to Karlsruhe Hbf via Firenze S.M.N. and Milano Centrale in around 11h 7m. Alternatively, you can take a bus from Siena to Karlsruhe Central Bus Station via Florence Villa Constanza Bus Station in around 13h 7m.
- Website
- lufthansa.com
Flights from Florence Peretola Airport to Stuttgart Airport via Munich International Airport
- Ave. Duration
- 4h 13m
- When
- Every day
- Estimated price
- €180–650
Flights from Florence Peretola Airport to Frankfurt
- Ave. Duration
- 1h 40m
- When
- Every day
- Estimated price
- €120–500
Flights from Florence Peretola Airport to Frankfurt via Munich International Airport
- Ave. Duration
- 3h 12m
- When
- Every day
- Estimated price
- €150–550
Flights from Pisa International Airport to Frankfurt
- Ave. Duration
- 1h 40m
- When
- Every day
- Estimated price
- €140–480
Flights from Bologna Guglielmo Marconi Airport to Frankfurt
- Ave. Duration
- 1h 35m
- When
- Every day
- Estimated price
- €100–440
Flights from Bologna Guglielmo Marconi Airport to Frankfurt via Munich International Airport
- Ave. Duration
- 3h 12m
- When
- Every day
- Estimated price
- €130–460
Flights from Florence Peretola Airport to Munich International Airport
- Ave. Duration
- 1h 15m
- When
- Every day
- Estimated price
- €170–550
- Phone
- +39.06.5210550
- Website
- Trenitalia
Train from Siena to Firenze S.M.N.
- Ave. Duration
- 1h 34m
- Frequency
- Hourly
- Estimated price
- €11–19
- Website
- Trenitalia
Train from Siena to Firenze S.M.N.
- Ave. Duration
- 1h 34m
- Frequency
- Hourly
- Estimated price
- €11–19
- Website
- Trenitalia
Train from Siena to Firenze S.M.N.
- Ave. Duration
- 1h 34m
- Frequency
- Hourly
- Estimated price
- €11–19
- Website
- Trenitalia
Train from Siena to Firenze S.M.N.
- Ave. Duration
- 1h 34m
- Frequency
- Hourly
- Estimated price
- €11–19
- Website
- Trenitalia
Train from Siena to Empoli
- Ave. Duration
- 1h 2m
- Frequency
- Every 30 minutes
- Estimated price
- €7–13
- Website
- Trenitalia
Train from Empoli to Pisa Centrale
- Ave. Duration
- 46 min
- Frequency
- Every 15 minutes
- Estimated price
- €5–10
- Website
- Trenitalia
Train from Siena to Firenze S.M.N.
- Ave. Duration
- 1h 34m
- Frequency
- Hourly
- Estimated price
- €11–19
- Website
- Trenitalia
Train from Firenze S.M.N. to Bologna Centrale
- Ave. Duration
- 1h 28m
- Frequency
- 4 times a day
- Estimated price
- €11–18
- Website
- Trenitalia
Train from Siena to Firenze S.M.N.
- Ave. Duration
- 1h 34m
- Frequency
- Hourly
- Estimated price
- €11–19
- Website
- Trenitalia
Train from Siena to Firenze S.M.N.
- Ave. Duration
- 1h 34m
- Frequency
- Hourly
- Estimated price
- €11–19
- Website
- Trenitalia
Rome2Rio's guide to FlixBus
Contact DetailsContact Details
- Phone
- +49 30 300 137 300
- [email protected]
- Website
- Flixbus
Bus from Siena to Florence Villa Constanza Bus Station
- Ave. Duration
- 50 min
- Frequency
- Every 3 hours
- Estimated price
- €5–8
- Website
- Flixbus
Bus from Siena to Florence Villa Constanza Bus Station
- Ave. Duration
- 50 min
- Frequency
- Every 3 hours
- Estimated price
- €5–8
- Website
- Flixbus
Bus from Florence Villa Constanza Bus Station to Karlsruhe central train station
- Ave. Duration
- 15h 10m
- Frequency
- Once daily
- Estimated price
- €65–110
- Website
- Flixbus
Want to know more about travelling around Germany
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
5 incredible day trips from Florence by train
Read the travel guide
Italy Travel Guides
Read the travel guide
Want to know more about Flixbus?
Read the travel guide
More Questions & Answers
Siena to Karlsruhe bus services, operated by FlixBus, arrive at Florence Villa Constanza Bus Station.
Siena to Karlsruhe train services, operated by Trenitalia, arrive at Firenze S.M.N. station.
Yes, the driving distance between Siena to Karlsruhe is 890 km. It takes approximately 8h 47m to drive from Siena to Karlsruhe.
Book your Siena to Karlsruhe train tickets online with Omio.
Book your Siena to Karlsruhe bus tickets online with Omio.
There are 896+ hotels available in Karlsruhe.





