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How to get fromSiena to Lyonby train (Trenitalia), bus, car, train, or plane

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There are 10 ways to get from Siena to Lyon by train (Trenitalia), bus, car, train, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train

    best
    1. Take the train from Siena to Firenze S.M.N.train train Re
    2. Take the train from Firenze S.M.N. to Milano Centraletrain train Fr
    3. Take the train from Milano Centrale to Lyon Part Dieutrain train Fr
    9h 50m
    €91–165

  2. Bus via Florence

    cheapest
    1. Take the bus from Siena-Via Tozzi to Firenze Autostazionebus bus 131R / ...
    2. Take the bus from Florence Villa Constanza Bus Station to Lyon Lyon Perrache Bus Stationbus bus Itabus
    14h 29m
    €47–83

  3. Bus

    1. Take the bus from Siena to Lyonbus bus 516 / ...
    12h
    €65–100

  4. Drive  727.3 km

    1. Drive from Siena to Lyoncar car 727.3 km
    8h 6m
    €118–171

  5. Train to Florence Peretola Airport, fly to Lyon–Saint Exupéry Airport

    1. Take the train from Siena to Firenze S.M.N.train train
    2. Fly from Florence Peretola Airport (FLR) to Lyon–Saint Exupéry Airport (LYS)plane plane FLR - LYS
    6h 4m
    €74–283

  6. Train via Turin (Trenitalia)

    1. Take the train from Siena to Firenze S.M.N.train train Re
    2. Take the train from Firenze S.M.N. to Torino Porta Susatrain train Fr
    3. Take the train from Torino Porta Susa to Lyon Part Dieutrain train Fr
    10h 20m
    €106–175

  7. Train, train to Fiumicino International Airport, fly to Lyon–Saint Exupéry Airport

    1. Take the train from Siena to Firenze S.M.N.train train
    2. Take the train from Firenze S.M.N. to Roma Terminitrain train
    3. Fly from Fiumicino International Airport (FCO) to Lyon–Saint Exupéry Airport (LYS)plane plane FCO - LYS
    8h 28m
    €108–322

  8. Train to Florence Peretola Airport, fly to Geneva International Airport, train

    1. Take the train from Siena to Firenze S.M.N.train train
    2. Fly from Florence Peretola Airport (FLR) to Geneva International Airport (GVA)plane plane FLR - GVA
    3. Take the train from Bellegarde to Lyon Part Dieutrain train
    10h 34m
    €138–341

  9. Train, train to Venice Marco Polo Airport, fly to Lyon–Saint Exupéry Airport

    1. Take the train from Siena to Firenze S.M.N.train train
    2. Take the train from Firenze S.M.N. to Venezia Mestretrain train
    3. Fly from Venice Marco Polo Airport (VCE) to Lyon–Saint Exupéry Airport (LYS)plane plane VCE - LYS
    9h 14m
    €88–313

  10. Train, train to Nice Côte D'Azur International Airport, fly to Lyon–Saint Exupéry Airport

    1. Take the train from Siena to Empolitrain train
    2. Take the train from Empoli to Pisa Centraletrain train
    3. Take the train from Pisa Centrale to Ventimigliatrain train
    4. Take the train from Ventimiglia to Saint-Laurent-du-Vartrain train
    5. Fly from Nice Côte D'Azur International Airport (NCE) to Lyon–Saint Exupéry Airport (LYS)plane plane NCE - LYS
    12h 3m
    €150–369

Siena to Lyon by train

Calendar14Weekly Trains
Duration9h 50mAverage Duration
Ticket€91Cheapest Price
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Comparing Your Travel Options

Map of how to get from Siena to Lyon.ExpandLaunch map view
  • Distance: 841.9 km
  • Duration: 9h 50m

What companies run services between Siena, Italy and Lyon, France?

You can take a train from Siena to Lyon Part Dieu via Firenze S.M.N. and Milano Centrale in around 9h 50m. Alternatively, FlixBus operates a bus from Siena to Lyon 5 times a week. Tickets cost €65–100 and the journey takes 12h.

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