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How to get fromSiena to Mainzby train, plane, train (Trenitalia), bus, or car

Find Transport to Mainz

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There are 6 ways to get from Siena to Mainz by train, plane, train (Trenitalia), bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Florence Peretola Airport, fly

    best
    1. Take the train from Siena to Firenze S.M.N.train train
    2. Fly from Florence Peretola Airport (FLR) to Frankfurt (FRA)plane plane FLR - FRA
    6h 6m
    €137–338

  2. Bus via Frankfurt am Main

    cheapest
    1. Take the bus from Siena to Florence Villa Constanza Bus Stationbus bus 1509 / ...
    2. Take the bus from Florence Villa Constanza Bus Station to Frankfurt central train stationbus bus N77 / ...
    20h 13m
    €103–178

  3. Train

    1. Take the train from Siena to Firenze S.M.N.train train Re
    2. Take the train from Firenze S.M.N. to Milano Centraletrain train Fr
    3. Take the train from Milano Centrale to Mannheim Hbftrain train Ec
    4. Take the train from Mannheim, Hauptbahnhof to Mainz, Hauptbahnhoftrain train S5 / ...
    13h 33m
    €173–325

  4. Bus

    1. Take the bus from Siena to Florence Villa Constanza Bus Stationbus bus 1509 / ...
    2. Take the bus from Florence Villa Constanza Bus Station to Wiesbaden Gartenfeldstraße P+Rbus bus
    17h 26m
    €139–204

  5. Drive  1,023.7 km

    1. Drive from Siena to Mainzcar car 1,023.7 km
    9h 49m
    €166–240

  6. Train, train to Bologna Guglielmo Marconi Airport, fly

    1. Take the train from Siena to Firenze S.M.N.train train
    2. Take the train from Firenze S.M.N. to Bologna Centraletrain train
    3. Fly from Bologna Guglielmo Marconi Airport (BLQ) to Frankfurt (FRA)plane plane BLQ - FRA
    6h 43m
    €119–366

Siena to Mainz by train

Calendar8Weekly Trains
Duration13h 33mAverage Duration
Ticket€173Cheapest Price
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Comparing Your Travel Options

Map of how to get from Siena to Mainz.ExpandLaunch map view
  • Distance: 847.3 km
  • Duration: 6h 6m

What companies run services between Siena, Italy and Mainz, Germany?

You can take a train from Siena to Mainz, Hauptbahnhof via Firenze S.M.N., Milano Centrale, Mannheim Hbf, and Mannheim, Hauptbahnhof in around 13h 33m. Alternatively, you can take a bus from Siena to Wiesbaden-Mainz-Kastel Bahnhof via Florence Villa Constanza Bus Station, Wiesbaden Gartenfeldstraße P+R, and Wiesbaden Hauptbahnhof in around 17h 26m.

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