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How to get fromSiena to Sicilyby train, plane, ferry, bus, train (Trenitalia), car, or car ferry

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There are 11 ways to get from Siena to Sicily by train, plane, ferry, bus, train (Trenitalia), car, or car ferry

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Florence Peretola Airport, fly to Catania–Fontanarossa Airport

    best
    1. Take the train from Siena to Firenze S.M.N.train train
    2. Fly from Florence Peretola Airport (FLR) to Catania–Fontanarossa Airport (CTA)plane plane FLR - CTA
    4h 54m
    €45–204

  2. Train, ferry

    1. Take the train from Siena to Firenze S.M.N.train train Re
    2. Take the train from Firenze S.M.N. to Napoli Centraletrain train Fr
    3. Take the ferry from Naples Beverello to Port of Palermoferry ferry
    14h 23m
    €110–229

  3. Bus

    1. Take the bus from Siena to Palermobus bus N597
    16h 31m
    €93–147

  4. Train (Trenitalia)

    1. Take the train from Siena to Firenze S.M.N.train train Re
    2. Take the train from Firenze S.M.N. to Roma Terminitrain train Fr
    3. Take the train from Roma Termini to Palermo Centraletrain train Ic
    16h 32m
    €136–300

  5. Train to Florence Peretola Airport, fly to Palermo Airport

    1. Take the train from Siena to Firenze S.M.N.train train
    2. Fly from Florence Peretola Airport (FLR) to Palermo Airport (PMO)plane plane FLR - PMO
    5h 25m
    €77–206

  6. Train, train to Pisa International Airport, fly to Catania–Fontanarossa Airport

    1. Take the train from Siena to Empolitrain train
    2. Take the train from Empoli to Pisa Centraletrain train
    3. Fly from Pisa International Airport (PSA) to Catania–Fontanarossa Airport (CTA)plane plane PSA - CTA
    5h 9m
    €57–233

  7. Train, train to Pisa International Airport, fly to Palermo Airport

    1. Take the train from Siena to Empolitrain train
    2. Take the train from Empoli to Pisa Centraletrain train
    3. Fly from Pisa International Airport (PSA) to Palermo Airport (PMO)plane plane PSA - PMO
    5h 34m
    €56–255

  8. Train, train to Pisa International Airport, fly to Trapani Airport

    1. Take the train from Siena to Empolitrain train
    2. Take the train from Empoli to Pisa Centraletrain train
    3. Fly from Pisa International Airport (PSA) to Trapani Airport (TPS)plane plane PSA - TPS
    6h 7m
    €61–322

  9. Drive, car ferry

    1. Drive from Siena to Civitavecchia Portcar car
    2. Take the carferry from Civitavecchia Port to Palermo Portocarferry car ferry
    15h 44m
    €89–132

  10. Train via Chiusi (Trenitalia)

    1. Take the train from Siena to Chiusi-Chianciano T.train train Re
    2. Take the train from Chiusi-Chianciano T. to Roma Terminitrain train Re
    3. Take the train from Roma Termini to Palermo Centraletrain train Ic
    17h 40m
    €123–254

  11. Bus via Florence

    1. Take the bus from Siena-Via Tozzi to Firenze Autostazionebus bus 131R / ...
    2. Take the bus from Florence Villa Constanza Bus Station to Palermo Piazza Cairolibus bus
    22h 56m
    €199–280

Siena to Sicily by train, subway, ferry, foot, and bus

Calendar6Weekly Services
Duration14h 23mAverage Duration
Ticket€110Cheapest Price
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Questions & Answers

Map of how to get from Siena to Sicily.ExpandLaunch map view
  • Distance: 877.7 km
  • Duration: 4h 54m

What companies run services between Siena, Italy and Sicily, Italy?

FlixBus operates a bus from Siena to Palermo once daily. Tickets cost €90–150 and the journey takes 16h. Alternatively, you can take a train from Siena to Palermo Notarbartolo via Firenze S.M.N., Roma Termini, and Palermo Centrale in around 16h 32m.

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