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How to get fromSiena to Sicilyby train, plane, car, car ferry, train (Trenitalia), or bus

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There are 10 ways to get from Siena to Sicily by train, plane, car, car ferry, train (Trenitalia), or bus

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train to Florence Peretola Airport, fly to Catania–Fontanarossa Airport

    best
    1. Take the train from Siena to Firenze S.M.N.train train
    2. Fly from Florence Peretola Airport (FLR) to Catania–Fontanarossa Airport (CTA)plane plane FLR - CTA
    4h 54m
    €38–181

  2. Drive, car ferry

    1. Drive from Siena to Civitavecchia Portcar car
    2. Take the carferry from Civitavecchia Port to Palermo Portocarferry car ferry
    15h 44m
    €93–133

  3. Train

    1. Take the train from Siena to Firenze S.M.N.train train Re
    2. Take the train from Firenze S.M.N. to Roma Terminitrain train Fr
    3. Take the train from Roma Termini to Palermo Centraletrain train Ic
    16h 27m
    €136–247

  4. Bus

    1. Take the bus from Siena to Palermobus bus N597
    16h 27m
    €110–160

  5. Train to Florence Peretola Airport, fly to Palermo Airport

    1. Take the train from Siena to Firenze S.M.N.train train
    2. Fly from Florence Peretola Airport (FLR) to Palermo Airport (PMO)plane plane FLR - PMO
    5h 17m
    €46–222

  6. Train, train to Pisa International Airport, fly to Palermo Airport

    1. Take the train from Siena to Empolitrain train
    2. Take the train from Empoli to Pisa Centraletrain train
    3. Fly from Pisa International Airport (PSA) to Palermo Airport (PMO)plane plane PSA - PMO
    5h 20m
    €56–250

  7. Train, train to Pisa International Airport, fly to Catania–Fontanarossa Airport

    1. Take the train from Siena to Empolitrain train
    2. Take the train from Empoli to Pisa Centraletrain train
    3. Fly from Pisa International Airport (PSA) to Catania–Fontanarossa Airport (CTA)plane plane PSA - CTA
    5h 2m
    €57–219

  8. Train, train to Bologna Guglielmo Marconi Airport, fly to Catania–Fontanarossa Airport

    1. Take the train from Siena to Firenze S.M.N.train train
    2. Take the train from Firenze S.M.N. to Bologna Centraletrain train
    3. Fly from Bologna Guglielmo Marconi Airport (BLQ) to Catania–Fontanarossa Airport (CTA)plane plane BLQ - CTA
    5h 36m
    €42–259

  9. Train via Chiusi (Trenitalia)

    1. Take the train from Siena to Chiusi-Chianciano T.train train Re
    2. Take the train from Chiusi-Chianciano T. to Roma Terminitrain train Re
    3. Take the train from Roma Termini to Palermo Centraletrain train Ic
    17h 25m
    €123–216

  10. Bus via Florence

    1. Take the bus from Siena-Via Tozzi to Firenze Autostazionebus bus 131R / ...
    2. Take the bus from Florence Villa Constanza Bus Station to Palermo Piazza Cairolibus bus
    22h 52m
    €199–280

Siena to Sicily by train

Calendar28Weekly Trains
Duration16h 27mAverage Duration
Ticket€136Cheapest Price
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Comparing Your Travel Options

Map of how to get from Siena to Sicily.ExpandLaunch map view
  • Distance: 877.7 km
  • Duration: 4h 54m

What companies run services between Siena, Italy and Sicily, Italy?

You can take a train from Siena to Palermo Notarbartolo via Firenze S.M.N., Roma Termini, and Palermo Centrale in around 16h 27m. Alternatively, FlixBus operates a bus from Siena to Palermo once daily. Tickets cost €100–160 and the journey takes 16h.

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