There are 6 ways to get from Siesta Key to Florida Keys by bus (Flixbus, Greyhound), car, plane, bus, or shuttle
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Bus
best- Take the bus from Sarasota Cattlemen Transfer Center to Miami Airport Stationbus FlixBus 2421
- Take the bus from Miami Airport Station to Big Pine Keybus Greyhound US0720s
12h 38m$56–98Drive 331.3 mi
- Drive from Siesta Key to Florida Keyscar 331.3 mi
6h 42m$61–88Fly to Key West International Airport
- Fly from Sarasota–Bradenton International Airport (SRQ) to Key West International Airport (EYW)plane SRQ - EYW
8h 49m$138–498Bus, shuttle
- Take the bus from Bradenton/Sarasota - Mobil Gas Station to Miami Airportbus Tallahassee
- Take a shuttle bus from Miami, FL - International Airport to Summerland Key - Mote Marine LabTo the Keys
12h 38m$206–262Bus via Pembroke Pines
- Take the bus from Sarasota Cattlemen Transfer Center to Hollywood Sheridan Trirail Stationbus FlixBus 2421
- Take the bus from Miami Airport Station to Big Pine Keybus Greyhound US0720s
13h 34m$58–98Fly to Miami International Airport, shuttle
- Fly from Sarasota–Bradenton International Airport (SRQ) to Miami International Airport (MIA)plane SRQ - MIA
- Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FL
8h 9m$214–638
Siesta Key to Florida Keys by bus and foot
Comparing Your Travel Options
The cheapest way to get from Siesta Key to Florida Keys is to bus which costs $55 - $100 and takes 12h 38m.
The fastest way to get from Siesta Key to Florida Keys is to drive which takes 6h 42m and costs $60 - $90.
No, there is no direct bus from Siesta Key to Florida Keys. However, there are services departing from Ocean Blvd @ Avenida Madera NB and arriving at Sugarloaf Key - Lower - Sugarloaf Lodge via Downtown Transfer Station, Sarasota Cattlemen Transfer Center, Miami Airport Station and Big Pine Key - CVS / MM30. The journey, including transfers, takes approximately 12h 38m.
The distance between Siesta Key and Florida Keys is 394 miles. The road distance is 333.2 miles.
The best way to get from Siesta Key to Florida Keys without a car is to bus which takes 12h 38m and costs $55 - $100.
It takes approximately 12h 38m to get from Siesta Key to Florida Keys, including transfers.
Siesta Key to Florida Keys bus services, operated by Flixbus USA, depart from Sarasota Cattlemen Transfer Center station.
The best way to get from Siesta Key to Florida Keys is to bus which takes 12h 38m and costs $55 - $100. Alternatively, you can fly, which costs $130 - $500 and takes 8h 49m.
Siesta Key to Florida Keys bus services, operated by Flixbus USA, arrive at Miami Airport Station.
Yes, the driving distance between Siesta Key to Florida Keys is 333 miles. It takes approximately 6h 42m to drive from Siesta Key to Florida Keys.
What companies run services between Siesta Key, FL, USA and Florida Keys, FL, USA?
You can take a bus from Ocean Blvd @ Avenida Madera NB to Florida Keys via Main St @ Lemon Ave, Downtown Transfer Station, Cattlemen Transit Station, Sarasota Cattlemen Transfer Center, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 12h 38m. Alternatively, American Airlines, Delta, and Allegiant Air fly from Sarasota–Bradenton International Airport (SRQ) to Key West International Airport (EYW) every 4 hours.
- Website
- delta.com
Flights from Sarasota–Bradenton International Airport to Key West International Airport via Atlanta
- Ave. Duration
- 5h 45m
- When
- Every day
- Estimated price
- $120–600
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Sarasota Cattlemen Transfer Center to Miami Airport Station
- Ave. Duration
- 4h 35m
- Frequency
- 3 times a day
- Estimated price
- $30–55
- Schedules at
- Flixbus USA
Bus from Sarasota Cattlemen Transfer Center to Hollywood Sheridan Trirail Station
- Ave. Duration
- 4h 20m
- Frequency
- 6 times a week
- Estimated price
- $30–50
- Schedules at
- Flixbus USA
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Booking & Getting There
There are 969+ hotels available in Florida Keys.

