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How to get fromSikeston to Chicagoby car, plane, bus, train, or taxi

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There are 7 ways to get from Sikeston to Chicago by car, plane, bus, train, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Barkley Regional Airport, fly to Chicago O'Hare International Airport

    best
    1. Drive from Sikeston to Barkley Regional Airport (PAH)car car
    2. Fly from Barkley Regional Airport (PAH) to Chicago O'Hare International Airport (ORD)plane plane PAH - ORD
    3h 26m
    $52–290

  2. Bus

    1. Take the bus from Flying J - Matthews to Tornado Bus Co - Chicagobus bus Milwaukee
    8h 20m
    $115–143

  3. Drive, train (Amtrak)

    1. Drive from Sikeston to Fulton Amtrak Stationcar car
    2. Take the train from Fulton Amtrak Station to Chicago Union Stationtrain train City of New Orleans
    9h 34m
    $113–258

  4. Drive  395.2 mi

    1. Drive from Sikeston to Chicagocar car 395.2 mi
    6h 32m
    $73–105

  5. Bus to Williamson County Regional Airport, fly to Chicago O'Hare International Airport

    1. Take the bus from Flying J - Matthews to Marathon Gas Station - Marionbus bus
    2. Fly from Williamson County Regional Airport (MWA) to Chicago O'Hare International Airport (ORD)plane plane MWA - ORD
    5h 18m
    $138–301

  6. Taxi, bus to Lambert–St. Louis International Airport, fly to Chicago Midway International Airport

    1. Take the taxi from Sikeston to Cape Girardeautaxi taxi
    2. Take the bus from Cape Girardeau to St Louis Bus Stationbus bus
    3. Fly from Lambert–St. Louis International Airport (STL) to Chicago Midway International Airport (MDW)plane plane STL - MDW
    5h 55m
    $165–499

  7. Taxi, bus to Lambert–St. Louis International Airport, fly to Chicago O'Hare International Airport

    1. Take the taxi from Sikeston to Cape Girardeautaxi taxi
    2. Take the bus from Cape Girardeau to St Louis Bus Stationbus bus
    3. Fly from Lambert–St. Louis International Airport (STL) to Chicago O'Hare International Airport (ORD)plane plane STL - ORD
    6h 22m
    $385–849

Barkley Regional Airport (PAH) to Chicago O'Hare International Airport (ORD) flights

Calendar7Weekly Planes
Duration1h 28mAverage Duration
Ticket$42Cheapest Price
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Questions & Answers

Map of how to get from Sikeston to Chicago.ExpandLaunch map view
  • Distance: 415.9 mi
  • Duration: 3h 26m

What companies run services between Sikeston, MO, USA and Chicago, IL, USA?

Tornado Bus Company operates a bus from Flying J - Matthews to Tornado Bus Co - Chicago once daily. Tickets cost $80–100 and the journey takes 7h 24m.

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