There are 4 ways to get from Sikeston to Columbia by taxi, bus, car, or plane
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Taxi, bus (Greyhound)
best- Take the taxi from Sikeston to Cape Girardeautaxi
- Take the bus from Cape Girardeau to St Louis Bus Stationbus
- Take the bus from St Louis Bus Station to Columbiabus
6h 25m$132–186Drive 253.6 mi
cheapest- Drive from Sikeston to Columbiacar 253.6 mi
4h 22m$47–67Drive to Barkley Regional Airport, fly
- Drive from Sikeston to Barkley Regional Airport (PAH)car
- Fly from Barkley Regional Airport (PAH) to Columbia Regional Airport (COU)plane PAH - COU
6h 45m$130–460Bus to Williamson County Regional Airport, fly
- Take the bus from Flying J - Matthews to Marathon Gas Station - Marionbus
- Fly from Williamson County Regional Airport (MWA) to Columbia Regional Airport (COU)plane MWA - COU
8h$209–701
Barkley Regional Airport (PAH) to Columbia Regional Airport (COU) flights
Questions & Answers
The cheapest way to get from Sikeston to Columbia is to drive which costs $45 - $70 and takes 4h 22m.
The fastest way to get from Sikeston to Columbia is to drive which takes 4h 22m and costs $45 - $70.
The distance between Sikeston and Columbia is 290 miles. The road distance is 255 miles.
The best way to get from Sikeston to Columbia without a car is to taxi and bus which takes 6h 25m and costs $130 - $190.
It takes approximately 6h 25m to get from Sikeston to Columbia, including transfers.
Yes, the driving distance between Sikeston to Columbia is 255 miles. It takes approximately 4h 22m to drive from Sikeston to Columbia.
There are 57+ hotels available in Columbia.
What companies run services between Sikeston, MO, USA and Columbia, MO, USA?
There is no direct connection from Sikeston to Columbia. However, you can take the taxi to Cape Girardeau, take the bus to St Louis Bus Station, then take the bus to Columbia. Alternatively, you can drive from Sikeston to Columbia in around 4h 22m.
- Website
- united.com
Flights from Barkley Regional Airport to Columbia Regional Airport via Chicago O'Hare
- Ave. Duration
- 7h 23m
- When
- Every day
- Estimated price
- $70–380
Flights from Williamson County Regional Airport to Columbia Regional Airport via Chicago O'Hare
- Ave. Duration
- 5h 45m
- When
- Every day
- Estimated price
- $80–450
- Website
- aa.com
Flights from Williamson County Regional Airport to Columbia Regional Airport via Chicago O'Hare
- Ave. Duration
- 6h 6m
- When
- Every day
- Estimated price
- $80–450
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- Greyhound
Bus from Cape Girardeau to St Louis Bus Station
- Ave. Duration
- 1h 50m
- Frequency
- Once daily
- Estimated price
- $17–35
- Website
- Greyhound
Bus from St Louis Bus Station to Columbia
- Ave. Duration
- 3h
- Frequency
- Twice daily
- Estimated price
- $21–40
- Website
- Greyhound
- Phone
- +1 888 358 6762
- [email protected]
- Website
- Tornado Bus Company
Bus from Flying J - Matthews to Marathon Gas Station - Marion
- Ave. Duration
- 1h 30m
- Frequency
- Once daily
- Estimated price
- $40–140
- Schedules at
- Tornado Bus Company
- Adults 11-59
- $40–140
- Ave. Duration
- 35 min
- Estimated price
- $90–120
Want to know more about travelling around United States
Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.
Related travel guides
Travelling to the US: What do I need to know?
Read the travel guide
Need to know: Greyhound
Read the travel guide




