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How to get fromSikeston to Destinby taxi, bus, plane, car, or train

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There are 6 ways to get from Sikeston to Destin by taxi, bus, plane, car, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Taxi, bus to Lambert–St. Louis International Airport, fly to Northwest Florida Beaches International Airport

    best
    1. Take the taxi from Sikeston to Cape Girardeautaxi taxi
    2. Take the bus from Cape Girardeau to St Louis Bus Stationbus bus
    3. Fly from Lambert–St. Louis International Airport (STL) to Northwest Florida Beaches International Airport (ECP)plane plane STL - ECP
    4. Take the taxi from Northwest Florida Beaches International Airport (ECP) to Destintaxi taxi
    7h 3m
    $332–764

  2. Drive  597.7 mi

    cheapest
    1. Drive from Sikeston to Destincar car 597.7 mi
    10h 55m
    $110–158

  3. Drive, train, bus, taxi

    1. Drive from Sikeston to Fulton Amtrak Stationcar car
    2. Take the train from Fulton Amtrak Station to New Orleans Union Passenger Terminaltrain train
    3. Take the train from New Orleans Union Passenger Terminal to Gulfport Amtrak Statrain train
    4. Take the bus from Gulfport to Crestviewbus bus
    5. Take the taxi from Crestview to Destintaxi taxi
    20h 3m
    $473–703

  4. Taxi, bus

    1. Take the taxi from Sikeston to Cape Girardeautaxi taxi
    2. Take the bus from Cape Girardeau to New Orleans Bus Stationbus bus
    3. Take the bus from New Orleans Bus Station to Biloxi Transit Centerbus bus
    4. Take the bus from Biloxi to Crestviewbus bus
    5. Take the taxi from Crestview to Destintaxi taxi
    22h 45m
    $343–470

  5. Taxi, bus to Lambert–St. Louis International Airport, fly to Pensacola International Airport

    1. Take the taxi from Sikeston to Cape Girardeautaxi taxi
    2. Take the bus from Cape Girardeau to St Louis Bus Stationbus bus
    3. Fly from Lambert–St. Louis International Airport (STL) to Pensacola International Airport (PNS)plane plane STL - PNS
    4. Take the taxi from Pensacola-Airport-PNS to Destintaxi taxi
    7h 7m
    $297–654

  6. Taxi, bus to Midamerica St. Louis Airport, fly to Destin–Fort Walton Beach Airport

    1. Take the taxi from Sikeston to Cape Girardeautaxi taxi
    2. Take the bus from Cape Girardeau to St Louis Bus Stationbus bus
    3. Fly from Midamerica St. Louis Airport (BLV) to Destin–Fort Walton Beach Airport (VPS)plane plane BLV - VPS
    6h 39m
    $245–607

Lambert–St. Louis International Airport (STL) to Northwest Florida Beaches International Airport (ECP) flights

Calendar31Weekly Planes
Duration3h 23mAverage Duration
Ticket$79Cheapest Price
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Comparing Your Travel Options

Map of how to get from Sikeston to Destin.ExpandLaunch map view
  • Distance: 847.8 mi
  • Duration: 7h 3m

What companies run services between Sikeston, MO, USA and Destin, FL, USA?

There is no direct connection from Sikeston to Destin. However, you can take the taxi to Cape Girardeau, take the bus to St Louis Bus Station, walk to CIVIC CENTER station, take the train to LAMBERT AIRPORT TERMINAL #1 station, walk to Lambert–St. Louis International Airport (STL) airport, fly to Northwest Florida Beaches International Airport (ECP), then take the taxi to Destin. Alternatively, you can drive to Fulton Amtrak Station, take the train to New Orleans Union Passenger Terminal, take the train to Gulfport Amtrak Sta, walk to Gulfport, take the bus to Crestview, then take the taxi to Destin.

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