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How to get fromSikeston to Knoxvilleby car, plane, bus, or taxi

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There are 6 ways to get from Sikeston to Knoxville by car, plane, bus, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive to Barkley Regional Airport, fly

    best
    1. Drive from Sikeston to Barkley Regional Airport (PAH)car car
    2. Fly from Barkley Regional Airport (PAH) to Mcghee Tyson Airport (TYS)plane plane PAH - TYS
    8h 9m
    $215–835

  2. Drive 369.7 mi

    cheapest
    1. Drive from Sikeston to Knoxvillecar car 369.7 mi
    6h 25m
    $68–98

  3. Bus via Brentwood

    1. Take the bus from Flying J - Matthews to Tornado Bus Co - West Memphisbus bus
    2. Take the bus from Tornado Bus Co - West Memphis to Tornado Bus Co - Nashvillebus bus
    3. Take the bus from Nashville, TN to New York, NYbus bus Ny
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    36h 31m
    $367–617

  4. Taxi to Cape Girardeau Municipal Airport, fly

    1. Take the taxi from Sikeston to Cape Girardeau Municipal Airport (CGI)taxi taxi
    2. Fly from Cape Girardeau Municipal Airport (CGI) to Mcghee Tyson Airport (TYS)plane plane CGI - TYS
    6h 12m
    $289–920

  5. Bus

    1. Take the bus from Flying J - Matthews to Tornado Bus Co - West Memphisbus bus
    2. Take the bus from Memphis - Summer Ave to New Yorkbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    39h 21m
    $409–634

  6. Taxi, bus

    1. Take the taxi from Sikeston to Cape Girardeautaxi taxi
    2. Take the bus from Cape Girardeau to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Port Authority Bus Terminalbus bus
    4. Take the bus from New York to Knoxvillebus bus Nyc
    41h 47m
    $455–719

Barkley Regional Airport (PAH) to Mcghee Tyson Airport (TYS) flights

Calendar18Weekly Planes
Duration8h 18mAverage Duration
Ticket$153Cheapest Price
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Questions & Answers

Map of how to get from Sikeston to Knoxville.ExpandLaunch map view
  • Distance: 347.4 mi
  • Duration: 8h 9m

What companies run services between Sikeston, MO, USA and Knoxville, TN, USA?

You can take a vehicle from Sikeston to Knoxville via Flying J - Matthews, Tornado Bus Co - West Memphis, Tornado Bus Co - Nashville, Walmart Station Outbound, Nashville, TN, New York, NY, and Knoxville, TN in around 36h 31m.

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Bus operators
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