Rome2Rio

How to get fromSikeston to Knoxvilleby car, plane, bus, or taxi

Find Transport to Knoxville

See all options

There are 5 ways to get from Sikeston to Knoxville by car, plane, bus, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive, fly

    best
    1. Drive from Sikeston to Barkley Regional Airport (PAH)car car
    2. Fly from Barkley Regional Airport (PAH) to Mcghee Tyson Airport (TYS)plane plane PAH - TYS
    8h 8m
    $265–1,184

  2. Drive  369.7 mi

    cheapest
    1. Drive from Sikeston to Knoxvillecar car 369.7 mi
    6h 25m
    $66–95

  3. Bus via Brentwood

    1. Take the bus from Flying J - Matthews to Tornado Bus Co - West Memphisbus bus
    2. Take the bus from Tornado Bus Co - West Memphis to Tornado Bus Co - Nashvillebus bus
    3. Take the bus from Nashville, TN to New York, NYbus bus Ny
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    36h 31m
    $338–432

  4. Bus

    1. Take the bus from Flying J - Matthews to Tornado Bus Co - West Memphisbus bus
    2. Take the bus from Memphis - Summer Ave to New Yorkbus bus
    3. Take the bus from New York to Knoxvillebus bus Nyc
    39h 19m
    $390–544

  5. Taxi, bus

    1. Take the taxi from Sikeston to Cape Girardeautaxi taxi
    2. Take the bus from Cape Girardeau to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Port Authority Bus Terminalbus bus
    4. Take the bus from New York to Knoxvillebus bus Nyc
    41h 47m
    $488–689

Barkley Regional Airport (PAH) to Mcghee Tyson Airport (TYS) flights

Calendar21Weekly Planes
Duration7h 57mAverage Duration
Ticket$207Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Sikeston to Knoxville.ExpandLaunch map view
  • Distance: 347.4 mi
  • Duration: 8h 8m

What companies run services between Sikeston, MO, USA and Knoxville, TN, USA?

You can take a vehicle from Sikeston to Knoxville via Flying J - Matthews, Tornado Bus Co - West Memphis, Tornado Bus Co - Nashville, Walmart Station Outbound, Nashville, TN, New York, NY, and Knoxville, TN in around 36h 31m.

Airlines
Bus operators
Other operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

Booking & Getting There