Rome2Rio

How to get fromSikeston to Lexingtonby bus, car, plane, or train

Find Transport to Lexington

See all options

There are 7 ways to get from Sikeston to Lexington by bus, car, plane, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, drive

    best
    1. Take the bus from Flying J - Matthews to Tornado Bus Co - West Memphisbus bus
    2. Take the bus from Tornado Bus Co - West Memphis to La Tropicana - Louisville, KYbus bus
    3. Drive from Middletown Station @ Target to Lexingtoncar car
    14h 43m
    $163–386

  2. Drive 318.1 mi

    cheapest
    1. Drive from Sikeston to Lexingtoncar car 318.1 mi
    5h 30m
    $58–84

  3. Drive to Barkley Regional Airport, fly to Blue Grass Airport

    1. Drive from Sikeston to Barkley Regional Airport (PAH)car car
    2. Fly from Barkley Regional Airport (PAH) to Blue Grass Airport (LEX)plane plane PAH - LEX
    10h 53m
    $152–817

  4. Drive, train, bus

    1. Drive from Sikeston to Fulton Amtrak Stationcar car
    2. Take the train from Fulton Amtrak Station to Champaign-Urbanatrain train
    3. Take the bus from Champaign Intermodal Trans Ctr to Indianapolis Union Stationbus bus
    4. Take the bus from Indianapolis Union Station to Louisville, KYbus bus
    5. Drive from Middletown Station @ Target to Lexingtoncar car
    17h 43m
    $157–302

  5. Drive, bus to Nashville, fly to Louisville International Airport

    1. Drive from Sikeston to Paducah Bus Stationcar car
    2. Take the bus from Paducah Bus Station to Nashville Bus Stationbus bus
    3. Fly from Nashville (BNA) to Louisville International Airport (SDF)plane plane BNA - SDF
    4. Drive from Louisville-Airport-SDF to Lexingtoncar car
    7h 51m
    $103–505

  6. Bus to Williamson County Regional Airport, fly to Blue Grass Airport

    1. Take the bus from Flying J - Matthews to Marathon Gas Station - Marionbus bus
    2. Fly from Williamson County Regional Airport (MWA) to Blue Grass Airport (LEX)plane plane MWA - LEX
    11h 34m
    $241–1,088

  7. Drive, bus to Nashville, fly to Covington

    1. Drive from Sikeston to Paducah Bus Stationcar car
    2. Take the bus from Paducah Bus Station to Nashville Bus Stationbus bus
    3. Fly from Nashville (BNA) to Covington (CVG)plane plane BNA - CVG
    4. Drive from Covington (CVG) to Lexingtoncar car
    8h 7m
    $119–576

Barkley Regional Airport (PAH) to Blue Grass Airport (LEX) flights

Calendar21Weekly Planes
Duration8h 33mAverage Duration
Ticket$148Cheapest Price
See schedules

Questions & Answers

Map of how to get from Sikeston to Lexington.ExpandLaunch map view
  • Distance: 624 mi
  • Duration: 14h 43m

What companies run services between Sikeston, MO, USA and Lexington, KY, USA?

There is no direct connection from Sikeston to Lexington. However, you can take the taxi to Flying J - Matthews, take the bus to Tornado Bus Co - West Memphis, take the bus to La Tropicana - Louisville, KY, walk to Preston @ Vim, take the line 28 bus to W Jefferson @ S 5th, take the line 31 bus to Middletown Station @ Target, then drive to Lexington. Alternatively, you can drive from Sikeston to Lexington in around 5h 30m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound