There are 5 ways to get from Sikeston to Lexington by car, bus, or plane
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Drive, bus
best- Drive from Sikeston to Paducah Bus Stationcar
- Take the bus from Paducah Bus Station to Clarksville Park & Ridebus
- Take the bus from Clarksville Park & Ride to Louisville Bus Stationbus
- Drive from Middletown Station @ Target to Lexingtoncar
11h 16m$64–112Drive 318.1 mi
cheapest- Drive from Sikeston to Lexingtoncar 318.1 mi
5h 30m$58–84Drive to Barkley Regional Airport, fly
- Drive from Sikeston to Barkley Regional Airport (PAH)car
- Fly from Barkley Regional Airport (PAH) to Blue Grass Airport (LEX)plane PAH - LEX
10h 53m$82–407Bus, drive
- Take the bus from Flying J - Matthews to Tornado Bus Co - West Memphisbus
- Take the bus from Tornado Bus Co - West Memphis to La Tropicana - Louisville, KYbus
- Drive from Middletown Station @ Target to Lexingtoncar
14h 43m$149–206Bus to Williamson County Regional Airport, fly
- Take the bus from Flying J - Matthews to Marathon Gas Station - Marionbus
- Fly from Williamson County Regional Airport (MWA) to Blue Grass Airport (LEX)plane MWA - LEX
11h 4m$138–528
Barkley Regional Airport (PAH) to Blue Grass Airport (LEX) flights
Questions & Answers
The cheapest way to get from Sikeston to Lexington is to drive which costs $55 - $85 and takes 5h 30m.
The fastest way to get from Sikeston to Lexington is to drive which takes 5h 30m and costs $55 - $85.
The distance between Sikeston and Lexington is 425 miles. The road distance is 319.9 miles.
It takes approximately 11h 16m to get from Sikeston to Lexington, including transfers.
Lexington is 1h ahead of Sikeston. It is currently 3:04 PM in Sikeston and 4:04 PM in Lexington.
Yes, the driving distance between Sikeston to Lexington is 320 miles. It takes approximately 5h 30m to drive from Sikeston to Lexington.
There are 180+ hotels available in Lexington.
What companies run services between Sikeston, MO, USA and Lexington, KY, USA?
There is no direct connection from Sikeston to Lexington. However, you can drive to Paducah Bus Station, take the bus to Clarksville Park & Ride, take the bus to Louisville Bus Station, walk to Chestnut @ 13th, take the line 21 bus to Chestnut @ 8th, walk to S 5th @ W Jefferson, take the line 31 bus to Middletown Station @ Target, then drive to Lexington. Alternatively, you can drive from Sikeston to Lexington in around 5h 30m.
- Website
- united.com
Flights from Barkley Regional Airport to Blue Grass Airport via Chicago O'Hare
- Ave. Duration
- 10h 58m
- When
- Every day
- Estimated price
- $70–390
- Phone
- +1 (855) 626-8585
- Website
- Flixbus USA
Bus from Paducah Bus Station to Clarksville Park & Ride
- Ave. Duration
- 1h 45m
- Frequency
- 5 times a week
- Estimated price
- $13–21
- Schedules at
- Flixbus USA
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