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How to get fromSikeston to Lexingtonby car, bus, or plane

Find Transport to Lexington

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There are 5 ways to get from Sikeston to Lexington by car, bus, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive, bus

    best
    1. Drive from Sikeston to Paducah Bus Stationcar car
    2. Take the bus from Paducah Bus Station to Clarksville Park & Ridebus bus
    3. Take the bus from Clarksville Park & Ride to Louisville Bus Stationbus bus
    4. Drive from Middletown Station @ Target to Lexingtoncar car
    11h 16m
    $64–112
  2. Drive  318.1 mi

    cheapest
    1. Drive from Sikeston to Lexingtoncar car 318.1 mi
    5h 30m
    $58–84
  3. Drive to Barkley Regional Airport, fly

    1. Drive from Sikeston to Barkley Regional Airport (PAH)car car
    2. Fly from Barkley Regional Airport (PAH) to Blue Grass Airport (LEX)plane plane PAH - LEX
    10h 53m
    $82–407
  4. Bus, drive

    1. Take the bus from Flying J - Matthews to Tornado Bus Co - West Memphisbus bus
    2. Take the bus from Tornado Bus Co - West Memphis to La Tropicana - Louisville, KYbus bus
    3. Drive from Middletown Station @ Target to Lexingtoncar car
    14h 43m
    $149–206
  5. Bus to Williamson County Regional Airport, fly

    1. Take the bus from Flying J - Matthews to Marathon Gas Station - Marionbus bus
    2. Fly from Williamson County Regional Airport (MWA) to Blue Grass Airport (LEX)plane plane MWA - LEX
    11h 4m
    $138–528

Barkley Regional Airport (PAH) to Blue Grass Airport (LEX) flights

Calendar21Weekly Planes
Duration10h 58mAverage Duration
Ticket$72Cheapest Price
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Questions & Answers

What companies run services between Sikeston, MO, USA and Lexington, KY, USA?

There is no direct connection from Sikeston to Lexington. However, you can drive to Paducah Bus Station, take the bus to Clarksville Park & Ride, take the bus to Louisville Bus Station, walk to Chestnut @ 13th, take the line 21 bus to Chestnut @ 8th, walk to S 5th @ W Jefferson, take the line 31 bus to Middletown Station @ Target, then drive to Lexington. Alternatively, you can drive from Sikeston to Lexington in around 5h 30m.

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