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How to get fromSikeston to Louisvilleby car, bus, or plane

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There are 4 ways to get from Sikeston to Louisville by car, bus, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Drive, bus

    best
    1. Drive from Sikeston to Paducah Bus Stationcar car
    2. Take the bus from Paducah Bus Station to Clarksville Park & Ridebus bus
    3. Take the bus from Clarksville Park & Ride to Louisville Bus Stationbus bus
    7h 42m
    $55–97

  2. Drive 276.4 mi

    cheapest
    1. Drive from Sikeston to Louisvillecar car 276.4 mi
    4h 48m
    $51–73

  3. Drive to Barkley Regional Airport, fly

    1. Drive from Sikeston to Barkley Regional Airport (PAH)car car
    2. Fly from Barkley Regional Airport (PAH) to Louisville International Airport (SDF)plane plane PAH - SDF
    9h 34m
    $106–568

  4. Bus to Williamson County Regional Airport, fly

    1. Take the bus from Flying J - Matthews to Marathon Gas Station - Marionbus bus
    2. Fly from Williamson County Regional Airport (MWA) to Louisville International Airport (SDF)plane plane MWA - SDF
    10h 20m
    $180–789

Barkley Regional Airport (PAH) to Louisville International Airport (SDF) flights

Calendar21Weekly Planes
Duration8h 53mAverage Duration
Ticket$99Cheapest Price
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Questions & Answers

Map of how to get from Sikeston to Louisville.ExpandLaunch map view
  • Distance: 335.1 mi
  • Duration: 7h 42m

What companies run services between Sikeston, MO, USA and Louisville, KY, USA?

There is no direct connection from Sikeston to Louisville. However, you can drive to Paducah Bus Station, take the bus to Clarksville Park & Ride, then take the bus to Louisville Bus Station. Alternatively, you can drive from Sikeston to Louisville in around 4h 48m.

Airlines
Bus operators

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