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How to get fromSikeston to Milwaukeeby bus, car, train, taxi, or plane

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There are 6 ways to get from Sikeston to Milwaukee by bus, car, train, taxi, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus

    best
    1. Take the bus from Flying J - Matthews to Water & Chicago - Circle Kbus bus Milwaukee
    9h 19m
    $130–155

  2. Drive to Barkley Regional Airport, fly to Chicago O'Hare International Airport, bus

    cheapest
    1. Drive from Sikeston to Barkley Regional Airport (PAH)car car
    2. Fly from Barkley Regional Airport (PAH) to Chicago O'Hare International Airport (ORD)plane plane PAH - ORD
    3. Take the bus from Chicago to Milwaukee Intermodal Stationbus bus
    5h 11m
    $63–311

  3. Drive, train (Amtrak)

    1. Drive from Sikeston to Fulton Amtrak Stationcar car
    2. Take the train from Fulton Amtrak Station to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Milwaukeetrain train
    12h 3m
    $135–308

  4. Drive  482.9 mi

    1. Drive from Sikeston to Milwaukeecar car 482.9 mi
    8h 6m
    $89–128

  5. Taxi, bus to Lambert–St. Louis International Airport, fly to General Mitchell International Airport

    1. Take the taxi from Sikeston to Cape Girardeautaxi taxi
    2. Take the bus from Cape Girardeau to St Louis Bus Stationbus bus
    3. Fly from Lambert–St. Louis International Airport (STL) to General Mitchell International Airport (MKE)plane plane STL - MKE
    5h 55m
    $596–997

  6. Bus to Williamson County Regional Airport, fly to Chicago O'Hare International Airport, bus

    1. Take the bus from Flying J - Matthews to Marathon Gas Station - Marionbus bus
    2. Fly from Williamson County Regional Airport (MWA) to Chicago O'Hare International Airport (ORD)plane plane MWA - ORD
    3. Take the bus from Chicago to Milwaukee Intermodal Stationbus bus
    7h 3m
    $149–322

Lambert–St. Louis International Airport (STL) to General Mitchell International Airport (MKE) flights

Calendar17Weekly Planes
Duration1h 30mAverage Duration
Ticket$83Cheapest Price
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Questions & Answers

Map of how to get from Sikeston to Milwaukee.ExpandLaunch map view
  • Distance: 501.4 mi
  • Duration: 9h 19m

What companies run services between Sikeston, MO, USA and Milwaukee, WI, USA?

Tornado Bus Company operates a bus from Flying J - Matthews to Water & Chicago - Circle K once daily. Tickets cost $100–120 and the journey takes 9h 5m.

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