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How to get fromSimpsonville to Florida Keysby plane, bus (Flixbus, Greyhound), taxi, bus, train, car, or shuttle

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There are 7 ways to get from Simpsonville to Florida Keys by plane, bus (Flixbus, Greyhound), taxi, bus, train, car, or shuttle

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Greenville–Spartanburg International Airport to Key West International Airport

    best
    1. Fly from Greenville–Spartanburg International Airport (GSP) to Key West International Airport (EYW)plane plane GSP - EYW
    7h 8m
    $191–550

  2. Drive to Asheville Regional Airport, fly to Key West International Airport

    cheapest
    1. Drive from Simpsonville to Asheville-Airport-AVLcar car
    2. Fly from Asheville Regional Airport (AVL) to Key West International Airport (EYW)plane plane AVL - EYW
    6h 10m
    $148–430

  3. Bus

    1. Take the bus from Taqueria Guadalajara - Greenville to Atlantabus bus
    2. Take the bus from Atlanta Bus Station to Miami Airport Stationbus bus
    3. Take the bus from Miami Airport Station to Big Pine Keybus bus
    25h 7m
    $194–346

  4. Taxi, bus, train

    1. Take the taxi from Simpsonville to Servicios Zapata - Spartanburgtaxi taxi
    2. Take the bus from Servicios Zapata - Spartanburg to Charlottebus bus
    3. Take the train from Charlotte Amtrak Station to Carytrain train
    4. Take the train from Cary to Miami Amtrak Stationtrain train
    5. Take the bus from Miami Airport Station to Big Pine Keybus bus
    36h 17m
    $478–966

  5. Drive 860.8 mi

    1. Drive from Simpsonville to Florida Keyscar car 860.8 mi
    14h 48m
    $158–227

  6. Fly Greenville–Spartanburg International Airport to Miami International Airport, shuttle

    1. Fly from Greenville–Spartanburg International Airport (GSP) to Miami International Airport (MIA)plane plane GSP - MIA
    2. Take a shuttle bus from Miami, FL - International Airport to Big Pine Key, FLshuttle bus
    7h 48m
    $276–710

  7. Fly Greenville–Spartanburg International Airport to Fort Lauderdale–Hollywood International Airport, shuttle

    1. Fly from Greenville–Spartanburg International Airport (GSP) to Fort Lauderdale–Hollywood International Airport (FLL)plane plane GSP - FLL
    2. Take a shuttle bus from Fort Lauderdale, FL - International Airport to Big Pine Key, FLshuttle bus
    8h 19m
    $351–1,050

Greenville–Spartanburg International Airport (GSP) to Key West International Airport (EYW) flights

Calendar47Weekly Planes
Duration5h 16mAverage Duration
Ticket$79Cheapest Price
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Questions & Answers

Map of how to get from Simpsonville to Florida Keys.ExpandLaunch map view
  • Distance: 749 mi
  • Duration: 7h 8m

What companies run services between Simpsonville, SC, USA and Florida Keys, FL, USA?

Delta, American Airlines, and Breeze Airways fly from Greenville–Spartanburg International Airport (GSP) to Key West International Airport (EYW) every 4 hours. Alternatively, you can take a vehicle from Simpsonville to Florida Keys via Taqueria Guadalajara - Greenville, Atlanta, Doraville Station, Garnett Station, Atlanta Bus Station, Miami Airport Station, Big Pine Key, Big Pine Key - CVS / MM30, and Sugarloaf Key - Lower - Sugarloaf Lodge in around 25h 7m.

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