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How to get fromSimpsonville to Indianapolisby plane, bus (Flixbus), car, or bus (Greyhound)

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There are 5 ways to get from Simpsonville to Indianapolis by plane, bus (Flixbus), car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Greenville–Spartanburg International Airport

    best
    1. Fly from Greenville–Spartanburg International Airport (GSP) to Indianapolis (IND)plane plane GSP - IND
    4h 46m
    $151–698

  2. Drive 502.4 mi

    cheapest
    1. Drive from Simpsonville to Indianapoliscar car 502.4 mi
    9h 48m
    $92–133

  3. Bus

    1. Take the bus from Taqueria Guadalajara - Greenville to Atlantabus bus Charlotte
    2. Take the bus from Atlanta Bus Station to Indianapolisbus bus FlixBus 2512
    17h 6m
    $174–352

  4. Drive to Asheville Regional Airport, fly

    1. Drive from Simpsonville to Asheville-Airport-AVLcar car
    2. Fly from Asheville Regional Airport (AVL) to Indianapolis (IND)plane plane AVL - IND
    5h 41m
    $98–518

  5. Bus via 510 & 601 Connection

    1. Take the bus from Taqueria Guadalajara - Greenville to Atlantabus bus Charlotte
    2. Take the bus from Atlanta Bus Station to Indianapolis Union Stationbus bus Greyhound US0100
    18h 43m
    $156–346

Greenville–Spartanburg International Airport (GSP) to Indianapolis (IND) flights

Calendar128Weekly Planes
Duration4h 20mAverage Duration
Ticket$110Cheapest Price
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Questions & Answers

Map of how to get from Simpsonville to Indianapolis.ExpandLaunch map view
  • Distance: 429.5 mi
  • Duration: 4h 46m

What companies run services between Simpsonville, SC, USA and Indianapolis, IN, USA?

Delta, American Airlines, and two other airlines fly from Greenville–Spartanburg International Airport (GSP) to Indianapolis (IND) hourly. Alternatively, you can take a vehicle from Simpsonville to Indianapolis via Taqueria Guadalajara - Greenville, Atlanta, Doraville Station, Garnett Station, and Atlanta Bus Station in around 17h 6m.

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