Rome2Rio

How to get fromSimpsonville to Louisvilleby plane, bus (Amtrak), car, bus (Greyhound, Flixbus, Amtrak), or bus (Greyhound)

Find Transport to Louisville

See all options

There are 5 ways to get from Simpsonville to Louisville by plane, bus (Amtrak), car, bus (Greyhound, Flixbus, Amtrak), or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Greenville–Spartanburg International Airport (GSP) to Louisville International Airport (SDF)plane plane GSP - SDF
    4h 38m
    $135–649

  2. Drive 389.6 mi

    cheapest
    1. Drive from Simpsonville to Louisvillecar car 389.6 mi
    8h 18m
    $72–103

  3. Bus

    1. Take the bus from Taqueria Guadalajara - Greenville to Atlantabus bus
    2. Take the bus from Grand Hyatt Atlanta in Buckhead to Omni Nashville Hotelbus bus
    3. Take the bus from Nashville to Louisville, KYbus bus
    14h 12m
    $249–317

  4. Bus via Atlanta

    1. Take the bus from Taqueria Guadalajara - Greenville to Atlantabus bus
    2. Take the bus from Atlanta Bus Station to Nashville Bus Stationbus bus
    3. Take the bus from Nashville to Louisville, KYbus bus
    14h 22m
    $134–222

  5. Bus #2

    1. Take the bus from Taqueria Guadalajara - Greenville to Atlantabus bus
    2. Take the bus from Atlanta Bus Station to Cincinnati Bus Stationbus bus
    3. Take the bus from Greyhound Station Cincinnati to Louisville, KY Bus Stationbus bus
    19h 14m
    $136–262

Greenville–Spartanburg International Airport (GSP) to Louisville International Airport (SDF) flights

Calendar66Weekly Planes
Duration4h 30mAverage Duration
Ticket$99Cheapest Price
See schedules

Questions & Answers

Map of how to get from Simpsonville to Louisville.ExpandLaunch map view
  • Distance: 319.3 mi
  • Duration: 4h 38m

What companies run services between Simpsonville, SC, USA and Louisville, KY, USA?

Southwest Airlines, Delta, and two other airlines fly from Greenville–Spartanburg International Airport (GSP) to Louisville International Airport (SDF) every 3 hours. Alternatively, you can take a vehicle from Simpsonville to Louisville, KY via Taqueria Guadalajara - Greenville, Atlanta, Doraville Station, Lenox Station, Lenox Station - Bay C, Peachtree Rd @ Highland Dr, Grand Hyatt Atlanta in Buckhead, Omni Nashville Hotel, Peabody Station Outbound, Fulton Station Outbound, and Nashville in around 14h 12m.

Airlines
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers