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How to get fromSimpsonville to Louisvilleby plane, bus (Greyhound, Flixbus, Amtrak), car, bus (Amtrak), or bus (Greyhound)

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There are 5 ways to get from Simpsonville to Louisville by plane, bus (Greyhound, Flixbus, Amtrak), car, bus (Amtrak), or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Greenville–Spartanburg International Airport (GSP) to Louisville International Airport (SDF)plane plane GSP - SDF
    4h 38m
    $135–649

  2. Drive 389.6 mi

    cheapest
    1. Drive from Simpsonville to Louisvillecar car 389.6 mi
    8h 18m
    $72–103

  3. Bus via Atlanta

    1. Take the bus from Taqueria Guadalajara - Greenville to Atlantabus bus
    2. Take the bus from Atlanta Bus Station to Nashville Bus Stationbus bus
    3. Take the bus from Nashville to Louisville, KYbus bus
    14h 21m
    $154–327

  4. Bus

    1. Take the bus from Taqueria Guadalajara - Greenville to Atlantabus bus
    2. Take the bus from Grand Hyatt Atlanta in Buckhead to Omni Nashville Hotelbus bus
    3. Take the bus from Nashville to Louisville, KYbus bus
    14h 33m
    $264–417

  5. Bus #2

    1. Take the bus from Taqueria Guadalajara - Greenville to Atlantabus bus
    2. Take the bus from Atlanta Bus Station to Cincinnati Bus Stationbus bus
    3. Take the bus from Greyhound Station Cincinnati to Louisville, KY Bus Stationbus bus
    19h 13m
    $160–382

Greenville–Spartanburg International Airport (GSP) to Louisville International Airport (SDF) flights

Calendar95Weekly Planes
Duration4h 25mAverage Duration
Ticket$98Cheapest Price
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Questions & Answers

Map of how to get from Simpsonville to Louisville.ExpandLaunch map view
  • Distance: 319.3 mi
  • Duration: 4h 38m

What companies run services between Simpsonville, SC, USA and Louisville, KY, USA?

Southwest Airlines, Delta, and three other airlines fly from Greenville–Spartanburg International Airport (GSP) to Louisville International Airport (SDF) hourly. Alternatively, you can take a vehicle from Simpsonville to Louisville, KY via Taqueria Guadalajara - Greenville, Atlanta, Doraville Station, Garnett Station, Atlanta Bus Station, and Nashville in around 14h 21m.

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