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How to get fromSimpsonville to Panama City Beachby plane, bus (Flixbus, Greyhound), or car

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There are 5 ways to get from Simpsonville to Panama City Beach by plane, bus (Flixbus, Greyhound), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Greenville–Spartanburg International Airport to Northwest Florida Beaches International Airport

    best
    1. Fly from Greenville–Spartanburg International Airport (GSP) to Northwest Florida Beaches International Airport (ECP)plane plane GSP - ECP
    4h 26m
    $154–511

  2. Drive 441.9 mi

    cheapest
    1. Drive from Simpsonville to Panama City Beachcar car 441.9 mi
    8h 10m
    $81–117

  3. Bus

    1. Take the bus from Taqueria Guadalajara - Greenville to Atlantabus bus
    2. Take the bus from Atlanta Bus Station to Tallahasseebus bus
    3. Take the bus from Tallahassee to Panama City Beach Bus Stationbus bus
    14h 50m
    $153–329

  4. Drive to Asheville Regional Airport, fly to Northwest Florida Beaches International Airport

    1. Drive from Simpsonville to Asheville-Airport-AVLcar car
    2. Fly from Asheville Regional Airport (AVL) to Northwest Florida Beaches International Airport (ECP)plane plane AVL - ECP
    5h 8m
    $116–411

  5. Fly Greenville–Spartanburg International Airport to Destin–Fort Walton Beach Airport, drive

    1. Fly from Greenville–Spartanburg International Airport (GSP) to Destin–Fort Walton Beach Airport (VPS)plane plane GSP - VPS
    2. Drive from Destin–Fort Walton Beach Airport (VPS) to Panama City Beachcar car
    5h 9m
    $114–462

Greenville–Spartanburg International Airport (GSP) to Northwest Florida Beaches International Airport (ECP) flights

Calendar90Weekly Planes
Duration5h 11mAverage Duration
Ticket$67Cheapest Price
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Questions & Answers

Map of how to get from Simpsonville to Panama City Beach.ExpandLaunch map view
  • Distance: 408.1 mi
  • Duration: 4h 26m

What companies run services between Simpsonville, SC, USA and Panama City Beach, FL, USA?

Delta, Southwest Airlines, and two other airlines fly from Greenville–Spartanburg International Airport (GSP) to Northwest Florida Beaches International Airport (ECP) hourly. Alternatively, you can take a vehicle from Simpsonville to Panama City Beach via Taqueria Guadalajara - Greenville, Atlanta, Doraville Station, Garnett Station, Atlanta Bus Station, Tallahassee, and Panama City Beach Bus Station in around 14h 50m.

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