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How to get fromSimpsonville to St. Louisby plane, bus (Greyhound, Flixbus), or car

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There are 5 ways to get from Simpsonville to St. Louis by plane, bus (Greyhound, Flixbus), or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly from Greenville–Spartanburg International Airport

    best
    1. Fly from Greenville–Spartanburg International Airport (GSP) to Lambert–St. Louis International Airport (STL)plane plane GSP - STL
    4h 19m
    $162–749

  2. Drive to Asheville Regional Airport, fly

    cheapest
    1. Drive from Simpsonville to Asheville-Airport-AVLcar car
    2. Fly from Asheville Regional Airport (AVL) to Lambert–St. Louis International Airport (STL)plane plane AVL - STL
    5h 36m
    $114–619

  3. Bus

    1. Take the bus from Taqueria Guadalajara - Greenville to Atlantabus bus Charlotte
    2. Take the bus from Atlanta Bus Station to St Louis Bus Stationbus bus Greyhound US0186
    17h 6m
    $174–372

  4. Drive 661.1 mi

    1. Drive from Simpsonville to St. Louiscar car 661.1 mi
    11h 19m
    $121–175

  5. Drive to Columbia, fly

    1. Drive from Simpsonville to Columbia-Airport-CAEcar car
    2. Fly from Columbia (CAE) to Lambert–St. Louis International Airport (STL)plane plane CAE - STL
    5h 55m
    $270–1,327

Greenville–Spartanburg International Airport (GSP) to Lambert–St. Louis International Airport (STL) flights

Calendar119Weekly Planes
Duration4h 58mAverage Duration
Ticket$119Cheapest Price
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Questions & Answers

Map of how to get from Simpsonville to St. Louis.ExpandLaunch map view
  • Distance: 550.1 mi
  • Duration: 4h 19m

What companies run services between Simpsonville, SC, USA and St. Louis, MO, USA?

Southwest Airlines, Delta, and two other airlines fly from Greenville–Spartanburg International Airport (GSP) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, you can take a vehicle from Simpsonville to St Louis Bus Station via Taqueria Guadalajara - Greenville, Atlanta, Doraville Station, Garnett Station, and Atlanta Bus Station in around 17h 6m.

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