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How to get fromSioux City to Mayo Clinicby bus, shuttle, car, or plane

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There are 6 ways to get from Sioux City to Mayo Clinic by bus, shuttle, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, shuttle

    best
    1. Take the bus from Sioux City to Sioux Fallsbus bus
    2. Take the bus from Sioux Falls to Albert Leabus bus
    3. Take the bus from Albert Lea to Owatonnabus bus
    4. Take a shuttle bus from Owatonna, MN to Rochestershuttle bus
    9h 45m
    $102–183

  2. Drive 270 mi

    cheapest
    1. Drive from Sioux City to Mayo Cliniccar car 270 mi
    4h 40m
    $50–72

  3. Bus, fly to Rochester

    1. Take the bus from Sioux City to Sioux Fallsbus bus
    2. Fly from Sioux Falls (FSD) to Rochester (RST)plane plane FSD - RST
    9h 5m
    $91–401

  4. Bus via Burnsville

    1. Take the bus from Sioux City to Sioux Fallsbus bus
    2. Take the bus from Sioux Falls to Burnsvillebus bus
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    11h 11m
    $152–196

  5. Bus

    1. Take the bus from Sioux City to Sioux Fallsbus bus
    2. Take the bus from Sioux Falls to Minneapolis-St. Paulbus bus
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    13h 32m
    $158–206

  6. Bus, fly to Minneapolis–Saint Paul International Airport

    1. Take the bus from Sioux City to Sioux Fallsbus bus
    2. Fly from Sioux Falls (FSD) to Minneapolis–Saint Paul International Airport (MSP)plane plane FSD - MSP
    3. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    7h 10m
    $147–463

Sioux Falls (FSD) to Rochester (RST) flights

Calendar36Weekly Planes
Duration5h 46mAverage Duration
Ticket$46Cheapest Price
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Questions & Answers

Map of how to get from Sioux City to Mayo Clinic.ExpandLaunch map view
  • Distance: 350.7 mi
  • Duration: 9h 45m

What companies run services between Sioux City, IA, USA and Mayo Clinic, MN, USA?

You can take a bus from Sioux City to Mayo Clinic via Sioux Falls, Burnsville Transit Station Bay B, Mall of America Transit Station Gate F, Mall of America Station, Terminal 2 Station, Minneapolis / St Paul Airport, and Groome Transportation Office - Rochester in around 11h 11m.

Airlines
Bus operators

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