Rome2Rio

How to get fromSioux Falls to Knoxvilleby plane, bus (Greyhound, Flixbus), bus, train, car, or bus (Greyhound)

Find Transport to Knoxville

See all options

There are 10 ways to get from Sioux Falls to Knoxville by plane, bus (Greyhound, Flixbus), bus, train, car, or bus (Greyhound)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Mcghee Tyson Airport

    best
    1. Fly from Sioux Falls (FSD) to Mcghee Tyson Airport (TYS)plane plane FSD - TYS
    6h 8m
    $216–872

  2. Fly to Nashville, drive

    cheapest
    1. Fly from Sioux Falls (FSD) to Nashville (BNA)plane plane FSD - BNA
    2. Drive from Nashville-Airport-BNA to Knoxvillecar car
    6h 11m
    $116–482

  3. Bus

    1. Take the bus from Sioux Falls to Omahabus bus
    2. Take the bus from Omaha to Chicagobus bus
    3. Take the bus from Chicago Bus Station to New York Midtownbus bus
    4. Take the bus from New York to Knoxvillebus bus Nyc
    45h 56m
    $450–730

  4. Bus, train via Kansas City

    1. Take the bus from Sioux Falls to Kansas Citybus bus
    2. Take the train from Kansas City to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Ny Moynihan Train Hall At Penn Stationtrain train
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    2d 4h
    $692–1,256

  5. Drive 1,076.7 mi

    1. Drive from Sioux Falls to Knoxvillecar car 1,076.7 mi
    18h 22m
    $197–284

  6. Fly to Chattanooga Metropolitan Airport, drive

    1. Fly from Sioux Falls (FSD) to Chattanooga Metropolitan Airport (CHA)plane plane FSD - CHA
    2. Drive from Chattanooga Metropolitan Airport (CHA) to Knoxvillecar car
    7h 35m
    $190–880

  7. Fly to Asheville Regional Airport, drive

    1. Fly from Sioux Falls (FSD) to Asheville Regional Airport (AVL)plane plane FSD - AVL
    2. Drive from Asheville-Airport-AVL to Knoxvillecar car
    8h 11m
    $118–486

  8. Bus via St. Louis

    1. Take the bus from Sioux Falls to Kansas Citybus bus
    2. Take the bus from Kansas City Bus Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Port Authority Bus Terminalbus bus
    4. Take the bus from New York to Knoxvillebus bus Nyc
    2d 5h
    $474–780

  9. Bus, train

    1. Take the bus from Sioux Falls to Omahabus bus
    2. Take the bus from Omaha to Indianapolisbus bus
    3. Take the train from Indianapolis to Ny Moynihan Train Hall At Penn Stationtrain train
    4. Take the bus from New York to Knoxvillebus bus Nyc
    2d 6h

  10. Bus, train #2

    1. Take the bus from Sioux Falls to Omahabus bus
    2. Take the bus from Omaha to Indianapolisbus bus
    3. Take the train from Indianapolis to Ny Moynihan Train Hall At Penn Stationtrain train
    4. Take the bus from New York, NY to Knoxville, TNbus bus Ny
    2d 6h

Sioux Falls (FSD) to Mcghee Tyson Airport (TYS) flights

Calendar76Weekly Planes
Duration5h 56mAverage Duration
Ticket$168Cheapest Price
See schedules

Questions & Answers

Map of how to get from Sioux Falls to Knoxville.ExpandLaunch map view
  • Distance: 879 mi
  • Duration: 6h 8m

What companies run services between Sioux Falls, SD, USA and Knoxville, TN, USA?

United Airlines, Delta, and American Airlines fly from Sioux Falls (FSD) to Mcghee Tyson Airport (TYS) every 2 hours. Alternatively, you can take a bus from The Bus Stop to Knoxville via Maple/Career NE corner, Sioux Falls, Omaha, Chicago Bus Station, New York Midtown, 23 St, East Broadway, New York, and Knoxville in around 45h 56m.

Airlines
Train operators
Bus operators

Want to know more about travelling around United States

Rome2Rio's Travel Guide series provide vital information for the global traveller. Filled with useful and timely travel information, the guides answer all the hard questions - such as 'How do I buy a ticket?', 'Should I book online before I travel? ', 'How much should I expect to pay?', 'Do the trains and buses have Wifi?' - to help you get the most out of your next trip.

Related travel guides

Need to know: Greyhound

Read the travel guideNeed to know: Greyhound

More Questions & Answers