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How to get fromSioux Falls to La Crosseby bus, train, car, or plane

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There are 8 ways to get from Sioux Falls to La Crosse by bus, train, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, train via Albert Lea

    best
    1. Take the bus from Sioux Falls to Albert Leabus bus
    2. Take the bus from Albert Lea to St. Paulbus bus
    3. Take the train from St. Paul-Minneapolis to La Crosse Amtrak Stationtrain train
    10h 52m
    $116–202

  2. Drive 296.7 mi

    cheapest
    1. Drive from Sioux Falls to La Crossecar car 296.7 mi
    4h 51m
    $55–79

  3. Fly to La Crosse

    1. Fly from Sioux Falls (FSD) to La Crosse (LSE)plane plane FSD - LSE
    6h 37m
    $90–404

  4. Bus

    1. Take the bus from Sioux Falls to Minneapolisbus bus Jefferson 702 / ...
    2. Take the bus from Minneapolis Bus Depot to La Crossebus bus Minneapolis / ...
    10h 55m
    $112–166

  5. Bus, train

    1. Take the bus from Sioux Falls to Minneapolis-St. Paulbus bus Jefferson Lines 926
    2. Take the train from St. Paul-Minneapolis to La Crosse Amtrak Stationtrain train Empire Builder / ...
    13h 8m
    $118–200

  6. Fly to Minneapolis–Saint Paul International Airport, train

    1. Fly from Sioux Falls (FSD) to Minneapolis–Saint Paul International Airport (MSP)plane plane FSD - MSP
    2. Take the train from St. Paul-Minneapolis to La Crosse Amtrak Stationtrain train
    6h 54m
    $94–440

  7. Fly to Rochester, bus

    1. Fly from Sioux Falls (FSD) to Rochester (RST)plane plane FSD - RST
    2. Take the bus from Rochester, MN to La Crossebus bus
    9h 47m
    $76–382

  8. Fly to Dane County Regional Airport-Truax Field, bus

    1. Fly from Sioux Falls (FSD) to Dane County Regional Airport-Truax Field (MSN)plane plane FSD - MSN
    2. Take the bus from Madison to UW La Crossebus bus
    8h 30m
    $124–558

Sioux Falls (FSD) to La Crosse (LSE) flights

Calendar35Weekly Planes
Duration6h 35mAverage Duration
Ticket$73Cheapest Price
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Questions & Answers

Map of how to get from Sioux Falls to La Crosse.ExpandLaunch map view
  • Distance: 409.5 mi
  • Duration: 10h 52m

What companies run services between Sioux Falls, SD, USA and La Crosse, WI, USA?

American Airlines and United Airlines fly from Sioux Falls (FSD) to La Crosse (LSE) 5 times a day. Alternatively, you can take a bus from The Bus Stop to La Crosse via Maple/Career NE corner, Sioux Falls, Minneapolis, and Minneapolis Bus Depot in around 10h 55m.

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