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How to get fromSioux Falls to Mayo Clinicby bus, shuttle, car, or plane

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There are 6 ways to get from Sioux Falls to Mayo Clinic by bus, shuttle, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Bus, shuttle

    best
    1. Take the bus from Sioux Falls to Albert Leabus bus
    2. Take the bus from Albert Lea to Owatonnabus bus
    3. Take a shuttle bus from Owatonna, MN to Rochestershuttle bus
    7h 55m
    $70–138

  2. Drive 234.4 mi

    cheapest
    1. Drive from Sioux Falls to Mayo Cliniccar car 234.4 mi
    3h 51m
    $43–62

  3. Fly to Rochester

    1. Fly from Sioux Falls (FSD) to Rochester (RST)plane plane FSD - RST
    7h 14m
    $48–342

  4. Bus via Burnsville

    1. Take the bus from Sioux Falls to Burnsvillebus bus Jefferson 702
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus Groome Transportation
    9h 21m
    $120–152

  5. Bus

    1. Take the bus from Sioux Falls to Minneapolis-St. Paulbus bus Jefferson Lines 926
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus Groome Transportation
    11h 42m
    $126–162

  6. Fly to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Sioux Falls (FSD) to Minneapolis–Saint Paul International Airport (MSP)plane plane FSD - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    5h 19m
    $104–404

Sioux Falls (FSD) to Rochester (RST) flights

Calendar36Weekly Planes
Duration5h 46mAverage Duration
Ticket$46Cheapest Price
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Questions & Answers

Map of how to get from Sioux Falls to Mayo Clinic.ExpandLaunch map view
  • Distance: 256.7 mi
  • Duration: 7h 55m

What companies run services between Sioux Falls, SD, USA and Mayo Clinic, MN, USA?

Delta, American Airlines, and United Airlines fly from Sioux Falls (FSD) to Rochester (RST) 5 times a day. Alternatively, you can take a bus from The Bus Stop to Mayo Clinic via Maple/Career NE corner, Sioux Falls, Burnsville Transit Station Bay B, Mall of America Transit Station Gate F, Mall of America Station, Terminal 2 Station, Minneapolis / St Paul Airport, and Groome Transportation Office - Rochester in around 9h 21m.

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