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How to get fromSioux Falls to Saint Charlesby plane, bus (Greyhound), car, bus, or train

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There are 4 ways to get from Sioux Falls to Saint Charles by plane, bus (Greyhound), car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Sioux Falls (FSD) to Lambert–St. Louis International Airport (STL)plane plane FSD - STL
    6h 22m
    $106–556

  2. Bus

    1. Take the bus from Sioux Falls to Kansas Citybus bus Jefferson Lines 706
    2. Take the bus from Kansas City Bus Station to St Louis Bus Stationbus bus Greyhound US0136 / ...
    15h 50m
    $136–220

  3. Drive 587.5 mi

    1. Drive from Sioux Falls to Saint Charlescar car 587.5 mi
    9h 40m
    $108–155

  4. Bus, train

    1. Take the bus from Sioux Falls to Omahabus bus
    2. Take the bus from Omaha to Bloomingtonbus bus
    3. Take the train from Bloomington-Normal to St. Louistrain train
    19h 30m

Sioux Falls (FSD) to Lambert–St. Louis International Airport (STL) flights

Calendar116Weekly Planes
Duration5h 33mAverage Duration
Ticket$104Cheapest Price
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Questions & Answers

Map of how to get from Sioux Falls to Saint Charles.ExpandLaunch map view
  • Distance: 487.6 mi
  • Duration: 6h 22m

What companies run services between Sioux Falls, SD, USA and Saint Charles, MO, USA?

Delta, United Airlines, and American Airlines fly from Sioux Falls (FSD) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, you can take a bus from The Bus Stop to 4375 Rider Trail North Sb via Maple/Career NE corner, Sioux Falls, Kansas City, Kansas City Bus Station, St Louis Bus Station, CIVIC CENTER station, NORTH HANLEY station, and North Hanley Transit Center in around 15h 50m.

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