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How to get fromSioux Falls to South Carolinaby plane, bus, train, car, or taxi

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There are 8 ways to get from Sioux Falls to South Carolina by plane, bus, train, car, or taxi

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Greenville–Spartanburg International Airport

    best
    1. Fly from Sioux Falls (FSD) to Greenville–Spartanburg International Airport (GSP)plane plane FSD - GSP
    6h 31m
    $176–746

  2. Fly to Charleston International Airport

    cheapest
    1. Fly from Sioux Falls (FSD) to Charleston International Airport (CHS)plane plane FSD - CHS
    7h 19m
    $114–554

  3. Bus, train

    1. Take the bus from Sioux Falls to Kansas Citybus bus
    2. Take the train from Kansas City to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Petersburg Amtrak Stationtrain train
    4. Take the train from Petersburg Amtrak Station to Charleston Amtrak Stationtrain train
    47h 50m
    $674–1,332

  4. Drive 1,424.9 mi

    1. Drive from Sioux Falls to Charlestoncar car 1,424.9 mi
    25h 7m
    $260–376

  5. Fly to Charlotte Douglas International Airport, taxi

    1. Fly from Sioux Falls (FSD) to Charlotte Douglas International Airport (CLT)plane plane FSD - CLT
    2. Take the taxi from Charlotte-Airport-CLT to Rock Hilltaxi taxi
    6h 30m
    $222–802

  6. Fly to Asheville Regional Airport, taxi

    1. Fly from Sioux Falls (FSD) to Asheville Regional Airport (AVL)plane plane FSD - AVL
    2. Take the taxi from Asheville-Airport-AVL to Greenvilletaxi taxi
    6h 51m
    $236–622

  7. Fly to Columbia

    1. Fly from Sioux Falls (FSD) to Columbia (CAE)plane plane FSD - CAE
    7h 23m
    $264–1,204

  8. Bus, train, taxi, drive

    1. Take the bus from Sioux Falls to Minneapolis-St. Paulbus bus
    2. Take the train from St. Paul-Minneapolis to Chicago Union Stationtrain train
    3. Take the train from Chicago Union Station to Savannah Stationtrain train
    4. Take the taxi from Savannah Station to Trolley Stop 10 - Coligny Beach Parktaxi taxi
    5. Drive from Trolley Stop 1 - Shelter Cove Towne Centre to Charlestoncar car
    2d 6h
    $838–1,562

Sioux Falls (FSD) to Greenville–Spartanburg International Airport (GSP) flights

Calendar56Weekly Planes
Duration6h 49mAverage Duration
Ticket$145Cheapest Price
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Questions & Answers

Map of how to get from Sioux Falls to South Carolina.ExpandLaunch map view
  • Distance: 994.9 mi
  • Duration: 6h 31m

What companies run services between Sioux Falls, SD, USA and South Carolina, USA?

American Airlines, United Airlines, and Delta fly from Sioux Falls (FSD) to Greenville–Spartanburg International Airport (GSP) every 4 hours.

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