There are 4 ways to get from Sioux Falls to St Charles, MO by plane, bus (Greyhound), car, bus, or train
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Fly
best- Fly from Sioux Falls (FSD) to Lambert–St. Louis International Airport (STL)plane FSD - STL
5h 45m$152–616Drive 598.8 mi
cheapest- Drive from Sioux Falls to St Charles, MOcar 598.8 mi
9h 55m$110–158Bus
- Take the bus from Sioux Falls to Kansas Citybus Jefferson Lines 706
- Take the bus from Kansas City Bus Station to St Louis Bus Stationbus Greyhound US0180s / ...
16h$188–288Bus, train
- Take the bus from Sioux Falls to Kansas Citybus Jefferson Lines 706
- Take the train from Kansas City to St. Louistrain Missouri River Runner / ...
17h 59m$240–400
Sioux Falls (FSD) to Lambert–St. Louis International Airport (STL) flights
Questions & Answers
The cheapest way to get from Sioux Falls to St Charles, MO is to drive which costs $100 - $160 and takes 9h 55m.
The fastest way to get from Sioux Falls to St Charles, MO is to fly which takes 5h 45m and costs $150 - $650.
No, there is no direct bus from Sioux Falls to St Charles, MO. However, there are services departing from The Bus Stop and arriving at North County Transit Center via Sioux Falls, Kansas City Bus Station and Civic Center Transit Center. The journey, including transfers, takes approximately 16h.
The distance between Sioux Falls and St Charles, MO is 497 miles. The road distance is 602.3 miles.
The best way to get from Sioux Falls to St Charles, MO without a car is to bus which takes 16h and costs $180 - $290.
It takes approximately 5h 45m to get from Sioux Falls to St Charles, MO, including transfers.
Sioux Falls to St Charles, MO bus services, operated by Jefferson Lines, depart from Sioux Falls station.
The best way to get from Sioux Falls to St Charles, MO is to fly which takes 5h 45m and costs $150 - $650. Alternatively, you can bus, which costs $180 - $290 and takes 16h.
Sioux Falls to St Charles, MO bus services, operated by Jefferson Lines, arrive at Kansas City station.
Yes, the driving distance between Sioux Falls to St Charles, MO is 602 miles. It takes approximately 9h 55m to drive from Sioux Falls to St Charles, MO.
What companies run services between Sioux Falls, SD, USA and St Charles, MO, USA?
Delta, United Airlines, and American Airlines fly from Sioux Falls (FSD) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, you can take a bus from The Bus Stop to St Charles, MO via Maple/Career NE corner, Sioux Falls, Kansas City, Kansas City Bus Station, St Louis Bus Station, Civic Center Transit Center, and North County Transit Center in around 16h.
- Website
- united.com
Flights from Sioux Falls to Lambert–St. Louis International Airport via Chicago O'Hare
- Ave. Duration
- 4h 46m
- When
- Every day
- Estimated price
- $100–550
Flights from Sioux Falls to Lambert–St. Louis International Airport via Denver
- Ave. Duration
- 6h 24m
- When
- Every day
- Estimated price
- $160–750
- Website
- aa.com
Flights from Sioux Falls to Lambert–St. Louis International Airport via Chicago O'Hare
- Ave. Duration
- 5h 47m
- When
- Every day
- Estimated price
- $100–550
Flights from Sioux Falls to Lambert–St. Louis International Airport via Dallas/Ft.Worth
- Ave. Duration
- 6h 1m
- When
- Every day
- Estimated price
- $160–750
- Website
- delta.com
Flights from Sioux Falls to Lambert–St. Louis International Airport via Minneapolis
- Ave. Duration
- 4h 32m
- When
- Every day
- Estimated price
- $100–550
Flights from Sioux Falls to Lambert–St. Louis International Airport via Atlanta
- Ave. Duration
- 6h 16m
- When
- Every day
- Estimated price
- $170–800
Rome2Rio's guide to Amtrak
Contact DetailsContact Details
- Phone
- +1 800-872-7245
- Website
- amtrak.com
Train from Kansas City to St. Louis
- Ave. Duration
- 5h 40m
- Frequency
- Twice daily
- Estimated price
- $90–190
- Website
- https://www.amtrak.com/home.html
- Phone
- +1-858-800-8898
- Website
- jeffersonlines.com
Bus from Sioux Falls to Kansas City
- Ave. Duration
- 8h 10m
- Frequency
- Once daily
- Estimated price
- $95–140
- Book at
- https://www.jeffersonlines.com
- Adult
- $95–140
Bus from Sioux Falls to Kansas City
- Ave. Duration
- 8h 10m
- Frequency
- Once daily
- Estimated price
- $95–140
- Book at
- https://www.jeffersonlines.com
- Adult
- $95–140
Rome2Rio's guide to Greyhound USA
Contact DetailsContact Details
- Phone
- +1 214-849-8100
- [email protected]
- Website
- greyhound.com
Bus from Kansas City Bus Station to St Louis Bus Station
- Ave. Duration
- 4h
- Frequency
- 4 times a day
- Estimated price
- $35–75
- Website
- https://www.greyhound.com/
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More Questions & Answers
There are 213+ hotels available in St Charles, MO.









