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How to get fromSioux Falls to St Charles, MOby plane, bus (Greyhound), car, bus, or train

Find Transport to St Charles, MO

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There are 4 ways to get from Sioux Falls to St Charles, MO by plane, bus (Greyhound), car, bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly

    best
    1. Fly from Sioux Falls (FSD) to Lambert–St. Louis International Airport (STL)plane plane FSD - STL
    5h 45m
    $152–616
  2. Drive 598.8 mi

    cheapest
    1. Drive from Sioux Falls to St Charles, MOcar car 598.8 mi
    9h 55m
    $110–158
  3. Bus

    1. Take the bus from Sioux Falls to Kansas Citybus bus Jefferson Lines 706
    2. Take the bus from Kansas City Bus Station to St Louis Bus Stationbus bus Greyhound US0180s / ...
    16h
    $188–288
  4. Bus, train

    1. Take the bus from Sioux Falls to Kansas Citybus bus Jefferson Lines 706
    2. Take the train from Kansas City to St. Louistrain train Missouri River Runner / ...
    17h 59m
    $240–400

Sioux Falls (FSD) to Lambert–St. Louis International Airport (STL) flights

Calendar116Weekly Planes
Duration5h 33mAverage Duration
Ticket$101Cheapest Price
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Questions & Answers

What companies run services between Sioux Falls, SD, USA and St Charles, MO, USA?

Delta, United Airlines, and American Airlines fly from Sioux Falls (FSD) to Lambert–St. Louis International Airport (STL) hourly. Alternatively, you can take a bus from The Bus Stop to St Charles, MO via Maple/Career NE corner, Sioux Falls, Kansas City, Kansas City Bus Station, St Louis Bus Station, Civic Center Transit Center, and North County Transit Center in around 16h.

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