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How to get fromSioux Falls to Tupeloby plane, car, bus (Greyhound, Flixbus), bus, or train

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There are 7 ways to get from Sioux Falls to Tupelo by plane, car, bus (Greyhound, Flixbus), bus, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly to Golden Triangle Regional Airport, drive

    best
    1. Fly from Sioux Falls (FSD) to Golden Triangle Regional Airport (GTR)plane plane FSD - GTR
    2. Drive from Golden Triangle Regional Airport (GTR) to Tupelocar car
    10h 12m
    $112–508

  2. Bus

    1. Take the bus from Sioux Falls to Kansas Citybus bus
    2. Take the bus from Kansas City Bus Station to St Louis Bus Stationbus bus
    3. Take the bus from St Louis Bus Station to Memphis Bus Stationbus bus
    4. Take the bus from Memphis Bus Station to Tupelobus bus
    23h 44m
    $210–328

  3. Drive  905.3 mi

    1. Drive from Sioux Falls to Tupelocar car 905.3 mi
    15h 42m
    $166–239

  4. Fly to Huntsville International Airport-Carl T Jones Field, drive

    1. Fly from Sioux Falls (FSD) to Huntsville International Airport-Carl T Jones Field (HSV)plane plane FSD - HSV
    2. Drive from Huntsville International Airport-Carl T Jones Field (HSV) to Tupelocar car
    8h 33m
    $154–736

  5. Fly to Memphis, bus

    1. Fly from Sioux Falls (FSD) to Memphis (MEM)plane plane FSD - MEM
    2. Take the bus from Memphis Bus Station to Tupelobus bus
    9h 53m
    $190–894

  6. Fly to Tupelo Regional Airport

    1. Fly from Sioux Falls (FSD) to Tupelo Regional Airport (TUP)plane plane FSD - TUP
    7h 41m
    $136–620

  7. Bus, train

    1. Take the bus from Sioux Falls to Kansas Citybus bus
    2. Take the train from Kansas City to St. Louistrain train
    3. Take the bus from St Louis Bus Station to Memphis Bus Stationbus bus
    4. Take the bus from Memphis Bus Station to Tupelobus bus
    25h 28m
    $328–514

Sioux Falls (FSD) to Golden Triangle Regional Airport (GTR) flights

Calendar32Weekly Planes
Duration8h 31mAverage Duration
Ticket$103Cheapest Price
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Comparing Your Travel Options

Map of how to get from Sioux Falls to Tupelo.ExpandLaunch map view
  • Distance: 891.2 mi
  • Duration: 10h 12m

What companies run services between Sioux Falls, SD, USA and Tupelo, MS, USA?

You can take a bus from The Bus Stop to Tupelo via Maple/Career NE corner, Sioux Falls, Kansas City, Kansas City Bus Station, St Louis Bus Station, Memphis Bus Station, and Tupelo in around 23h 44m. Alternatively, American Airlines, Corporate Flight Management Inc, and two other airlines fly from Sioux Falls (FSD) to Tupelo Regional Airport (TUP) twice daily.

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