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How to get fromSistine Chapel to Florenceby train (Trenitalia), bus, car, train, or plane

Find Transport to Florence

See all options

There are 7 ways to get from Sistine Chapel to Florence by train (Trenitalia), bus, car, train, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Train

    best
    1. Take the train from Roma S. Pietro to Roma Tiburtinatrain train Re / ...
    2. Take the train from Roma Tiburtina to Firenze Santa Maria Novellatrain train 8134 / ...
    2h 27m
    €31–52
  2. Line 62 bus, bus

    cheapest
    1. Take the bus from Cavalleggeri/Fornaci to Roma, Autostazione Tiburtinabus bus 62
    2. Take the bus from Roma, Autostazione Tiburtina to Florence Villa Constanza Bus Stationbus bus 510 / ...
    4h 29m
    €16–48
  3. Drive  275.5 km

    1. Drive from Sistine Chapel to Florencecar car 275.5 km
    2h 44m
    €50–72
  4. Train, fly to Florence Peretola Airport

    1. Take the train from Roma S. Pietro to Roma Trasteveretrain train
    2. Fly from Fiumicino International Airport (FCO) to Florence Peretola Airport (FLR)plane plane FCO - FLR
    3h 23m
    €64–207
  5. Line 64 bus, train

    1. Take the bus from Cavalleggeri/Fornaci to Terminibus bus 64 / ...
    2. Take the train from Roma Termini to Firenze S.M.N.train train Fr
    2h 33m
    €30–68
  6. Line 64 bus, train via Sistine Chapel

    1. Take the bus from Cavalleggeri/Fornaci to Terminibus bus 64 / ...
    2. Take the train from Roma Termini to Florence Santa Maria Novellatrain train 9928 / ...
    3h 20m
    €32–58
  7. Fly to Bologna Guglielmo Marconi Airport, train

    1. Fly from Fiumicino International Airport (FCO) to Bologna Guglielmo Marconi Airport (BLQ)plane plane FCO - BLQ
    2. Take the train from Bologna Centrale to Firenze S.M.N.train train
    4h 24m
    €67–206

Sistine Chapel to Florence by foot and bus

Calendar333Weekly Services
Duration4h 29mAverage Duration
Ticket€16Cheapest Price
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Comparing Your Travel Options

What companies run services between Sistine Chapel, Vatican City and Florence, Italy?

You can take a vehicle from Sistine Chapel to Firenze Santa Maria Novella via Roma S. Pietro and Roma Tiburtina in around 2h 27m. Alternatively, you can take a vehicle from Sistine Chapel to Florence Villa Constanza Bus Station via Cavalleggeri/Fornaci and Roma, Autostazione Tiburtina in around 4h 29m.

Airlines
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