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How to get fromSistine Chapel to Florenceby bus, train, car, or plane

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There are 6 ways to get from Sistine Chapel to Florence by bus, train, car, or plane

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Line 64 bus, train

    best
    1. Take the bus from Cavalleggeri/Fornaci to Terminibus bus 64 / ...
    2. Take the train from Roma Termini to Firenze S.M.N.train train Fr
    2h 19m
    €28–74

  2. Line 62 bus, bus

    cheapest
    1. Take the bus from Cavalleggeri/Fornaci to Roma, Autostazione Tiburtinabus bus 62
    2. Take the bus from Roma, Autostazione Tiburtina to Florence Villa Constanza Bus Stationbus bus 510 / ...
    4h 43m
    €16–44

  3. Drive  275.5 km

    1. Drive from Sistine Chapel to Florencecar car 275.5 km
    2h 44m
    €44–64

  4. Train, fly to Florence Peretola Airport

    1. Take the train from Roma S. Pietro to Roma Trasteveretrain train
    2. Fly from Fiumicino International Airport (FCO) to Florence Peretola Airport (FLR)plane plane FCO - FLR
    3h 9m
    €64–207

  5. Line 64 bus, train via Firenze Santa Maria Novella

    1. Take the bus from Cavalleggeri/Fornaci to Terminibus bus 64 / ...
    2. Take the train from Roma Termini to Firenze Santa Maria Novellatrain train 8134 / ...
    2h 37m
    €32–64

  6. Fly to Bologna Guglielmo Marconi Airport, train

    1. Fly from Fiumicino International Airport (FCO) to Bologna Guglielmo Marconi Airport (BLQ)plane plane FCO - BLQ
    2. Take the train from Bologna Centrale to Firenze S.M.N.train train
    3h 51m
    €56–197

Sistine Chapel to Florence by foot, bus, and train

Calendar669Weekly Services
Duration2h 19mAverage Duration
Ticket€28Cheapest Price
See schedules

Comparing Your Travel Options

Map of how to get from Sistine Chapel to Florence.ExpandLaunch map view
  • Distance: 267.2 km
  • Duration: 2h 19m

What companies run services between Sistine Chapel, Vatican City and Florence, Italy?

You can take a vehicle from Sistine Chapel to Florence Villa Constanza Bus Station via Cavalleggeri/Fornaci and Roma, Autostazione Tiburtina in around 4h 43m.

Airlines
Train operators
Bus operators

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