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How to get fromSkokie to Mayo Clinicby plane, train, bus, or car

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There are 7 ways to get from Skokie to Mayo Clinic by plane, train, bus, or car

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Chicago O'Hare International Airport to Rochester

    best
    1. Fly from Chicago O'Hare International Airport (ORD) to Rochester (RST)plane plane ORD - RST
    4h 7m
    $45–338

  2. Train, bus

    1. Take the train from Glenview Amtrak Station to Milwaukeetrain train Hiawatha Service / ...
    2. Take the bus from Milwaukee to Rochesterbus bus Jefferson Lines 966
    9h 6m
    $95–149

  3. Train, bus via Saint Paul

    1. Take the train from Glenview Amtrak Station to St. Paul-Minneapolistrain train Borealis / ...
    2. Take the bus from St. Paul to Rochesterbus bus Jefferson Lines 965
    10h 51m
    $151–304

  4. Drive 330.8 mi

    1. Drive from Skokie to Mayo Cliniccar car 330.8 mi
    5h 57m
    $61–88

  5. Fly Chicago O'Hare International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Chicago O'Hare International Airport (ORD) to Minneapolis–Saint Paul International Airport (MSP)plane plane ORD - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    5h 50m
    $276–510

  6. Fly Chicago Midway International Airport to Minneapolis–Saint Paul International Airport, bus

    1. Fly from Chicago Midway International Airport (MDW) to Minneapolis–Saint Paul International Airport (MSP)plane plane MDW - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    6h 50m
    $132–542

  7. Bus

    1. Take the bus from Multi-Modal/Rental Car Facility to 250 N. Lake St - Madison UW Campusbus bus Van Galder
    2. Take the bus from Madison to Rochesterbus bus Jefferson Lines 966
    9h 44m
    $75–128

Skokie to Mayo Clinic by train, bus, and foot

Calendar7Weekly Services
Duration9h 6mAverage Duration
Ticket$95Cheapest Price
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Questions & Answers

Map of how to get from Skokie to Mayo Clinic.ExpandLaunch map view
  • Distance: 288 mi
  • Duration: 4h 7m

What companies run services between Skokie, IL, USA and Mayo Clinic, MN, USA?

American Airlines, United Airlines, and Delta fly from Chicago O'Hare International Airport (ORD) to Rochester (RST) 5 times a day. Alternatively, you can take a bus from Dempster - Skokie CTA Station to Mayo Clinic via Multi-Modal/Rental Car Facility, 250 N. Lake St - Madison UW Campus, Madison, and Rochester in around 9h 44m.

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