There are 6 ways to get from Sophia Antipolis to Lyon by train (TGV, Trenitalia), bus, car, plane, or train (TGV)
Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.
Train via Marseille
best- Take the train from Cannes to Marseille St Charlestrain Tgv
- Take the train from Marseille St Charles to Lyon Part Dieutrain Tgv
4h 22m€110–238Bus via Nice - Airport Bus Station Terminal 1
cheapest- Take the bus from Nice - Airport Bus Station Terminal 1 to Lyon - Gerland Bus Stationbus BlaBlaCar Bus
8h 42m€32–67Drive 398.3 km
- Drive from Sophia Antipolis to Lyoncar 398.3 km
5h 27m€64–93Fly
- Fly from Nice Côte D'Azur International Airport (NCE) to Lyon–Saint Exupéry Airport (LYS)plane NCE - LYS
3h 30m€98–278Train (TGV)
- Take the train from Cannes to Lyon Part Dieutrain Tgv
5h 53m€105–155Bus
- Take the bus from Nice to Lyonbus N1719 / ...
9h 9m€45–76
Sophia Antipolis to Lyon by bus
Comparing Your Travel Options
The cheapest way to get from Sophia Antipolis to Lyon is to bus via Nice - Airport Bus Station Terminal 1 which costs €30 - €70 and takes 8h 42m.
The fastest way to get from Sophia Antipolis to Lyon is to fly which takes 3h 30m and costs €95 - €280.
No, there is no direct bus from Sophia Antipolis to Lyon station. However, there are services departing from Sophie Laffitte and arriving at Lyon - Gerland Bus Station via Nice - Airport Bus Station Terminal 1. The journey, including transfers, takes approximately 8h 42m.
No, there is no direct train from Sophia Antipolis to Lyon. However, there are services departing from Cannes and arriving at Lyon Part Dieu via Marseille St Charles. The journey, including transfers, takes approximately 4h 22m.
The distance between Sophia Antipolis and Lyon is 524 km. The road distance is 398.3 km.
The best way to get from Sophia Antipolis to Lyon without a car is to train via Marseille which takes 4h 22m and costs €110 - €240.
It takes approximately 4h 22m to get from Sophia Antipolis to Lyon, including transfers.
Sophia Antipolis to Lyon bus services, operated by BlaBlaCar Bus, depart from Nice - Airport Bus Station Terminal 1.
Sophia Antipolis to Lyon train services, operated by TGV inOui, depart from Cannes station.
The best way to get from Sophia Antipolis to Lyon is to train via Marseille which takes 4h 22m and costs €110 - €240. Alternatively, you can bus via Nice - Airport Bus Station Terminal 1, which costs €30 - €70 and takes 8h 42m, you could also fly, which costs €95 - €280 and takes 3h 30m.
What companies run services between Sophia Antipolis, France and Lyon, France?
You can take a vehicle from Sophia Antipolis to Lyon Part Dieu via Cannes and Marseille St Charles in around 4h 22m. Alternatively, BlaBlaCar Bus operates a bus from Nice - Airport Bus Station Terminal 1 to Lyon - Gerland Bus Station every 2 hours. Tickets cost €30–55 and the journey takes 7h 20m. FlixBus also services this route twice daily.
- Website
- airfrance.com
Flights from Nice Côte D'Azur International Airport to Lyon–Saint Exupéry Airport
- Ave. Duration
- 1h
- When
- Monday, Tuesday, Wednesday, Thursday, Friday, and Sunday
- Estimated price
- €40–290
Flights from Nice Côte D'Azur International Airport to Lyon–Saint Exupéry Airport via Bastia
- Ave. Duration
- 2h 40m
- When
- Monday, Wednesday, Friday, and Saturday
- Estimated price
- €150–550
- Phone
- +33 1 84 94 36 35
- Website
- TGV inOui
Train from Cannes to Marseille St Charles
- Ave. Duration
- 2h 1m
- Frequency
- Every 2 hours
- Estimated price
- €35–60
- Website
- TGV inOui
Train from Marseille St Charles to Lyon Part Dieu
- Ave. Duration
- 1h 46m
- Frequency
- Hourly
- Estimated price
- €60–95
- Website
- TGV inOui
Train from Cannes to Lyon Part Dieu
- Ave. Duration
- 3h 57m
- Frequency
- 5 times a day
- Estimated price
- €100–150
- Website
- TGV inOui
- Phone
- +3 318 576 2228
- Website
- BlaBlaCar Bus
Bus from Nice - Airport Bus Station Terminal 1 to Lyon - Gerland Bus Station
- Ave. Duration
- 7h 20m
- Frequency
- Every 2 hours
- Estimated price
- €30–55
- Website
- BlaBlaCar Bus
Want to know more about travelling around France
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Booking & Getting There
Sophia Antipolis to Lyon bus services, operated by BlaBlaCar Bus, arrive at Lyon - Gerland Bus Station.
Sophia Antipolis to Lyon train services, operated by TGV inOui, arrive at Marseille St Charles station.
Yes, the driving distance between Sophia Antipolis to Lyon is 398 km. It takes approximately 5h 27m to drive from Sophia Antipolis to Lyon.
There are 3923+ hotels available in Lyon.










