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How to get fromSouth Bend to Mayo Clinicby plane, bus (Greyhound, Flixbus), train, bus, car, or bus (Amtrak)

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There are 8 ways to get from South Bend to Mayo Clinic by plane, bus (Greyhound, Flixbus), train, bus, car, or bus (Amtrak)

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly South Bend to Rochester

    best
    1. Fly from South Bend (SBN) to Rochester (RST)plane plane SBN - RST
    6h 1m
    $75–427

  2. Train to Chicago O'Hare International Airport, fly to Rochester

    cheapest
    1. Take the train from South Bend Station to Chicago Union Stationtrain train
    2. Fly from Chicago O'Hare International Airport (ORD) to Rochester (RST)plane plane ORD - RST
    6h 48m
    $70–390

  3. Bus via Milwaukee

    1. Take the bus from South Bend, IN to Chicagobus bus
    2. Take the bus from Chicago Bus Station to Milwaukee Intermodal Stationbus bus
    3. Take the bus from Milwaukee to Rochesterbus bus
    11h 13m
    $97–152

  4. Train, bus

    1. Take the train from South Bend Station to Chicago Union Stationtrain train
    2. Take the train from Chicago Union Station to St. Paul-Minneapolistrain train
    3. Take the bus from St. Paul to Rochester, MNbus bus
    13h 14m
    $185–365

  5. Drive 436.5 mi

    1. Drive from South Bend to Mayo Cliniccar car 436.5 mi
    7h 29m
    $80–116

  6. Fly South Bend to Minneapolis–Saint Paul International Airport, bus

    1. Fly from South Bend (SBN) to Minneapolis–Saint Paul International Airport (MSP)plane plane SBN - MSP
    2. Take the bus from Minneapolis / St Paul Airport to Groome Transportation Office - Rochesterbus bus
    4h 47m
    $141–539

  7. Train, bus via Madison

    1. Take the train from South Bend Station to Chicago Union Stationtrain train
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    12h 11m
    $102–185

  8. Bus

    1. Take the bus from South Bend Station to Chicago Union Stationbus bus
    2. Take the bus from W Jackson Blvd, after S Clinton St to 250 N. Lake St - Madison UW Campusbus bus
    3. Take the bus from Madison to Rochesterbus bus
    12h 11m
    $105–172

South Bend to Mayo Clinic by train, bus, and foot

Calendar21Weekly Services
Duration13h 14mAverage Duration
Ticket$185Cheapest Price
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Questions & Answers

Map of how to get from South Bend to Mayo Clinic.ExpandLaunch map view
  • Distance: 361.5 mi
  • Duration: 6h 1m

What companies run services between South Bend, IN, USA and Mayo Clinic, MN, USA?

Delta, United Airlines, and American Airlines fly from South Bend (SBN) to Rochester (RST) every 3 hours. Alternatively, you can take a bus from South Bend, IN to Mayo Clinic via Chicago Bus Station, Milwaukee Intermodal Station, Milwaukee, and Rochester in around 11h 13m.

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