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How to get fromSouth Carolina to Chicagoby plane, car, bus, train (Amtrak), taxi, or train

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There are 10 ways to get from South Carolina to Chicago by plane, car, bus, train (Amtrak), taxi, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Greenville–Spartanburg International Airport to Chicago O'Hare International Airport

    best
    1. Fly from Greenville–Spartanburg International Airport (GSP) to Chicago O'Hare International Airport (ORD)plane plane GSP - ORD
    3h 12m
    $108–423

  2. Fly Charleston International Airport to Chicago O'Hare International Airport

    cheapest
    1. Fly from Charleston International Airport (CHS) to Chicago O'Hare International Airport (ORD)plane plane CHS - ORD
    5h 23m
    $71–339

  3. Drive, bus

    1. Drive from Charleston to Sonic at Walmartcar car
    2. Take the bus from Sonic at Walmart to Bluffton Transfer Centerbus bus 302
    3. Take the bus from Savannah to Atlantabus bus
    4. Take the bus from Atlanta Bus Station to Chicago Bus Stationbus bus
    23h 18m

  4. Train (Amtrak)

    1. Take the train from Charleston Amtrak Station to Petersburg Amtrak Stationtrain train Silver Meteor / ...
    2. Take the train from Petersburg Amtrak Station to Chicago Union Stationtrain train Floridian
    29h 10m
    $431–876

  5. Drive 873.5 mi

    1. Drive from Charleston to Chicagocar car 873.5 mi
    15h 58m
    $160–231

  6. Taxi to Charlotte Douglas International Airport, fly to Chicago O'Hare International Airport

    1. Take the taxi from Rock Hill to Charlotte-Airport-CLTtaxi taxi
    2. Fly from Charlotte Douglas International Airport (CLT) to Chicago O'Hare International Airport (ORD)plane plane CLT - ORD
    3h 35m
    $213–511

  7. Taxi to Charlotte Douglas International Airport, fly to Chicago Midway International Airport

    1. Take the taxi from Rock Hill to Charlotte-Airport-CLTtaxi taxi
    2. Fly from Charlotte Douglas International Airport (CLT) to Chicago Midway International Airport (MDW)plane plane CLT - MDW
    3h 13m
    $163–531

  8. Fly Columbia to Chicago O'Hare International Airport

    1. Fly from Columbia (CAE) to Chicago O'Hare International Airport (ORD)plane plane CAE - ORD
    4h 37m
    $144–756

  9. Fly Charleston International Airport to Chicago Midway International Airport

    1. Fly from Charleston International Airport (CHS) to Chicago Midway International Airport (MDW)plane plane CHS - MDW
    4h 54m
    $81–389

  10. Taxi to Charlotte Douglas International Airport, fly to South Bend, train

    1. Take the taxi from Rock Hill to Charlotte-Airport-CLTtaxi taxi
    2. Fly from Charlotte Douglas International Airport (CLT) to South Bend (SBN)plane plane CLT - SBN
    3. Take the train from South Bend Airport to Van Buren St.train train
    5h 33m
    $214–811

Greenville–Spartanburg International Airport (GSP) to Chicago O'Hare International Airport (ORD) flights

Calendar80Weekly Planes
Duration3h 18mAverage Duration
Ticket$69Cheapest Price
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Questions & Answers

Map of how to get from South Carolina to Chicago.ExpandLaunch map view
  • Distance: 609.6 mi
  • Duration: 3h 12m

What companies run services between South Carolina, USA and Chicago, IL, USA?

American Airlines, United Airlines, and Delta fly from Greenville–Spartanburg International Airport (GSP) to Chicago O'Hare International Airport (ORD) every 2 hours. Alternatively, you can take a vehicle from Charleston to Chicago Union Station via Charleston Amtrak Station and Petersburg Amtrak Station in around 29h 10m.

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