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How to get fromSouth Carolina to Chicagoby plane, train (Amtrak), car, bus, taxi, or train

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There are 10 ways to get from South Carolina to Chicago by plane, train (Amtrak), car, bus, taxi, or train

Select an option below to see step-by-step directions and to compare ticket prices and travel times in Rome2Rio's travel planner.

  1. Fly Greenville–Spartanburg International Airport to Chicago O'Hare International Airport

    best
    1. Fly from Greenville–Spartanburg International Airport (GSP) to Chicago O'Hare International Airport (ORD)plane plane GSP - ORD
    3h 11m
    $93–353

  2. Fly Columbia to Chicago O'Hare International Airport

    cheapest
    1. Fly from Columbia (CAE) to Chicago O'Hare International Airport (ORD)plane plane CAE - ORD
    4h 35m
    $58–306

  3. Train (Amtrak)

    1. Take the train from Charleston Amtrak Station to Petersburg Amtrak Stationtrain train Silver Meteor / ...
    2. Take the train from Petersburg Amtrak Station to Chicago Union Stationtrain train Floridian
    29h 10m
    $721–1,146

  4. Drive, bus, taxi, train

    1. Drive from Charleston to Sonic at Walmartcar car
    2. Take the bus from Sonic at Walmart to Bluffton Transfer Centerbus bus 302
    3. Take the taxi from Bluffton Transfer Center to Savannah Stationtaxi taxi
    4. Take the train from Savannah Station to Fayetteville Amtrak Stationtrain train
    5. Take the bus from Fayetteville Bus Station to Washington Union Stationbus bus
    6. Take the bus from Washington Union Station to Chicago Bus Stationbus bus
    34h 7m

  5. Drive  873.5 mi

    1. Drive from Charleston to Chicagocar car 873.5 mi
    15h 58m
    $160–231

  6. Taxi to Charlotte Douglas International Airport, fly to Chicago Midway International Airport

    1. Take the taxi from Rock Hill to Charlotte-Airport-CLTtaxi taxi
    2. Fly from Charlotte Douglas International Airport (CLT) to Chicago Midway International Airport (MDW)plane plane CLT - MDW
    3h 13m
    $153–521

  7. Taxi to Charlotte Douglas International Airport, fly to Chicago O'Hare International Airport

    1. Take the taxi from Rock Hill to Charlotte-Airport-CLTtaxi taxi
    2. Fly from Charlotte Douglas International Airport (CLT) to Chicago O'Hare International Airport (ORD)plane plane CLT - ORD
    3h 35m
    $138–421

  8. Fly Charleston International Airport to Chicago Midway International Airport

    1. Fly from Charleston International Airport (CHS) to Chicago Midway International Airport (MDW)plane plane CHS - MDW
    5h
    $91–469

  9. Taxi to Charlotte Douglas International Airport, fly to South Bend, train

    1. Take the taxi from Rock Hill to Charlotte-Airport-CLTtaxi taxi
    2. Fly from Charlotte Douglas International Airport (CLT) to South Bend (SBN)plane plane CLT - SBN
    3. Take the train from South Bend Airport to Van Buren St.train train
    5h 11m
    $160–513

  10. Fly Charleston International Airport to Chicago O'Hare International Airport

    1. Fly from Charleston International Airport (CHS) to Chicago O'Hare International Airport (ORD)plane plane CHS - ORD
    5h 31m
    $506–859

Greenville–Spartanburg International Airport (GSP) to Chicago O'Hare International Airport (ORD) flights

Calendar91Weekly Planes
Duration2h 45mAverage Duration
Ticket$51Cheapest Price
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Comparing Your Travel Options

Map of how to get from South Carolina to Chicago.ExpandLaunch map view
  • Distance: 609.6 mi
  • Duration: 3h 11m

What companies run services between South Carolina, USA and Chicago, IL, USA?

American Airlines, United Airlines, and Delta fly from Greenville–Spartanburg International Airport (GSP) to Chicago O'Hare International Airport (ORD) hourly. Alternatively, you can take a vehicle from Charleston to Chicago Union Station via Charleston Amtrak Station and Petersburg Amtrak Station in around 29h 10m.

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